Alpha Lipoic Sustain 300mg 120 tablets - sustained release alpha lipoic acid and biotin | Jarrow Formulas

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Alpha Lipoic Sustain 300mg 120 tabs -  alpha lipoic acid and biotin | Jarrow Formulas

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brand:Jarrow Formulas
best before:June 2021
appearance:time-released, tablets
diet:vegan, hypo-allergenic
details:economical size, 8+ items = -20% discount!
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Jarrow Formulas Alpha Lipoic Sustain 300mg 120 tablets  is a unique lipid and water soluble antioxidant that is a co-factor in energy production, helping to regulate glucose metabolism. ALA also promotes the synthesis of glutathione. Biotin is added for optimum ALA activity.

Alpha Lipoic Sustain 300 is available as a sustained release format so as to minimize gastric irritations and blood sugar fluctuations. Alpha Lipoic Acid is a disulfide molecule (containing two thiol groups). A thiol (or -SH) consists of a sulfur and a hydrogen atom. This unique anti-oxidant is both lipid- and water-soluble, a potent promoter of glutathione synthesis and a co-factor in energy production, helping to regulate glucose metabolism. Jarrow Formulas Alpha Lipoic Acid is made in Europe. Biotin is added for optimum ALA activity.

Alpha Lipoic Acid is the most abundant anti-oxidant produced in the liver, which serves as a liver detoxifying agent combined with N-Acetyl Cysteine to cleanse the liver by increasing Glutathione production in the liver . 

important
It is frequently stated that that the R- form of alpha lipoic acid is better and more stable than the mixed form. These claims have NOT been verified by other studies other than the one present by marketeers of R-ALA supplements and the respective manufacturers of R-ALA. All of the peer reviewed studies done on ALA have been done with the mix form NOT the R-ALA form which is not stable enough during production.

key benefits
• helps to control blood sugar levels and lowers dependence on insulin
• reduces abdominal body fat in overweight men and women
• controls carb cravings
• safe to use for a prolonged period

background reading

What is Alpha Lipoic Acid?
Alpha lipoic acid (aka ALA, lipoate, thioctic acid, dihydrolipoic acid) is an antioxidant and co-factor in glycolysis. Glycolysis is the initial process in most of the body’s pathways to breakdown glucose into useful forms of energy. Though critical to oxygen utilizing life, ALA is not a vitamin because it can be synthesized from essential fatty acids and the amino acid L-cysteine. However, no food is rich enough to serve as a good source.

Chemically, ALA has two juxtaposed sulfur atoms. When oxidized, the two sulfurs bond together (disulfide form). When reduced to dihydro-lipoic acid, each sulfur atom attaches to hydrogen (thiol form). ALA’s antioxidant chemistry is similar to glutathione, another sulfur-containing molecule and the most abundant antioxidant inside cells.

The Universal Antioxidant
ALA is reduced to its active form, dihydrolipoic acid, inside cells as the body needs it and is able to do so. The enzyme responsible for this, dihydrolipoamide dehydrogenase (LipHD), preferentially reduces the R-enantiomer of lipoic acid; this is why the R form is often considered the only biologically relevant form. However this may not be entirely accurate. Like vitamin C, ALA functions in water-based phases such as blood. However, like vitamin E, it also protects fatty tissues and membranes. ALA quenches free radicals— like hydroxyl, singlet-oxygen, and peroxynitrite—in both water and lipid phases, and protects against lipid peroxidation. It deactivates an unusually wide array of cell-damaging free radicals in many bodily systems.

Recycler Built for Two
ALA also enhances the potency of other antioxidants in both water- based (blood, cytosol) and lipid (membrane, blood fat) compartments. It recycles vitamin C directly and vitamin E indirectly in a unique and significant capacity, often preventing the symptoms of deficiency of these two critical vitamins.

Importantly, ALA increases glutathione levels in cells, in part by facilitating L-cysteine availability. It maintains the ratio of reduced-to- oxidized coenzyme Q10, which impacts mitochondrial health and energy production.

Blood Sugar Metabolism and Muscular Energy
Perhaps the most significant function of ALA is its important role in energy production from carbohydrates, participating in the multi-enzyme process on many levels. ALA stimulates insulin activity, reduces insulin resistance, and enhances glucose burning in obese laboratory animals. Humans with diabetes show a ~50% increase in glucose consumption. This also has implications for athletes and the overweight. Muscle activity requires efficient sugar metabolism. Similar improvements in sugar disposal occurred in brain tissue.

Alpha-lipoic acid is currently being studied for many age-related conditions, including heart and vascular health, sugar balance, neurological function, immune function, as well as fatigue and muscle strength. There is much protective promise in this powerful, broad- spectrum antioxidant.

Special Delivery Requirements—Maximum Benefits
Jarrow Formulas Alpha Lipoic Sustain® 300 is a bilayer Quick Release/Sustained Release ALA formulation. It maximizes blood levels while minimizing gastric irritation and blood sugar fluctuations. One- third of the ALA is releases rapidly and two-thirds releases slowly over time. This raises blood levels quickly while sustaining them. ALA does not accumulate in tissues, so it has no toxicity in suggested amounts. With wide distribution throughout the body, it is used in many ways. ALA finds particular utility in the eyes and brain, with neuroprotective and possibly cognitive-enhancing effects, especially in combination with acetyl-L-carnitine. It also has potential to reduce mercury retention.

Protection is highly dependent upon the dosing regimen. ALA is rapidly cleared from blood by the liver, so it is best supplemented in multiple, divided doses. Clinical studies typically employ 300 mg taken twice daily. Pharmaceutically designed Alpha Lipoic Sustain 300 keeps ALA in circulation for much longer periods than the usual tablet or capsule delivery. Sustained release may also help avoid stomach irritation experienced by sensitive individuals.

Note : Individuals who are diabetic, being treated for glucose control, pregnant or lactating should consult a health care professional before using this product.

The Importance of Biotin
Since biotin and ALA are similar, and transported by the same mechanism, elevated dietary ALA can interfere with biotin absorption and coenzyme functions. To protect against biotin deficiency, Alpha Lipoic Sustain 300 contains over 100% of the recommended daily allowance for biotin.

code MPN:
ALAS120-120036
brand :
Jarrow Formulas
best before:
June 2021
appearance:
  • time-released
  • tablets
audience :
  • adults
diet:
  • vegan
  • hypo-allergenic
details:
  • economical size
  • 8+ items = -20% discount!
quantity discount:
  • any 2+ = -5%!
  • any 3+ = -7.5%!
  • any 4+ = -10%!
  • any 5+ = -12.5%!
  • any 6+ = -15%!
  • any 8+ = -20%!
shipping costs:
  • €0 (NL) - €7,50 (BE/DE) - €9+ (EU)
information:
  • quantity discount is valid for any combination of products
  • free shipping above €30 (NL) - €60 (BE/DE) or €6 discount above €75 (EU)
  • keep out of reach of young children
  • a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
  • if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
  • books, probiotics and products bought in the SALE can NOT be returned

Why do we celebrate carnival?

Now we are in the midst of Carnival, it made sense to me as a true Southerner to explain the phenomenon to those who don't have an idea where it is all about.

Canival is celebrated in the period preceding Lent, mostly starting on Saturday and finishing on Shrove Tuesday, which is also known as Fat Tuesday or Mardi Gras, because it is the last day on which you can still indulge in fattening foods and alcohol.
The highlight of the carnival is the Sunday parade, for which floats are towed through the streets on which people are all dressed up, oftentimes wearing very intricate costumes. In my home region of Noord-Brabant, a lot of floats would mock local as well as national political issues.

From the anthropological point of view, carnival is a reversal ritual, in which social roles are reversed and norms about desired behavior are suspended. By wearing masks and costumes, it is much easier to make sure this happens and people also experience a heightened sense of social unity.

For those that are most actively involved in carnival, the actual season starts on November 11, the date when the council of Eleven (Elferrat) is chosen. That day is chosen not so much because it is the 'fools number' day, but because November 11 is 40 days before December 21 or midwinter.

While almost everyone knows what Carnival involves, very few actually know what Lent is. If you are among them, you are not the only one.
Lent is the short form of an old English and current Dutch word for spring and is probably also related to the word 'lengthening' (of days in spring).
For Christians, and specifically Catholics, Lent is the practice of fasting observed in the period before Easter.

Fasting is a loosely interpreted term here as it mostly doesn't involve complete abstinence from food, but instead of giving up indulgences for the period of Lent. Some give up on everything considered 'sinful' and others promise to give up one specific vice for Lent, such as alcohol, tobacco, candy, junkfood, sex or more recently also abstinence from social media like Facebook, Twitter or Instagram.
It is these habits that are increasingly also adopted by non-religious people, oftentimes also synchronized with friends who fast for religious reasons.

How reliable is the Glycemic index?

Almost everyone who's ever started a diet in the past decade, will have heard about the glycemic index (GI) and have been advised to eat predominantly foods that have a lower glycemic response, that is, foods that will not increase blood sugar level so much.

A high blood sugar level is closely associated with health problems such as diabetes and obesity, and it's easy to measure using a continuous glucose monitor.
A standard developed decades ago, called the glycemic index (GI), is used to rank foods based on how they affect blood sugar level and is a factor used by doctors and nutritionists to develop healthy diets. However, this system was based on studies that average how small groups of people responded to various foods.
This method of the glycemic index (GI) was developed at the University of Sydney where the glycemic response to foods were compared with those of glucose after an overnight fast.

The emphasis on the glycemic index led to an oversimplification of food items as being 'good' or 'wrong' based on their GI-ratings. It can even falsely portray unhealthy foods as “safe.”
Frequently agave syrup and coconut sugar are being advertised as “healthy” because of their low glycemic indexes, yet they lack nutrients such as fiber and vitamins and are nothing but 'empty sugar'.

A bigger problem with the glycemic index is that glycemic responses to foods are highly individual.
While the University of Sidney did their research on just 10 persons, a study with no less than 800 healthy and pre-diabetic volunteers, whose blood glucose levels were monitored every five minutes for a prolonged period of time, a startling difference between individual response on specific foods were shown.

How to eliminate toxins?

A while ago, there was a major uproar in the Dutch media about an advice given by a celeb health enthusiast to drink a glass of water with clay in order to 'detox' the body.
Unfortunately, while it is true that clay can bind to toxins, clay is not the best choice for two reasons. The clay itself can be polluted, but moreso, clay isn't the best option.

Balancing your blood sugar level

While it is fairly easy to spot hypoglycemia from shaky hands, acute headaches and listlessness, it is not so easy for hyperglycemia, unless your blood sugar reaches a dangerously high level. Then you may experience the same symptoms such as listlessness but also excessive thirst and blurry eye vision.

recommended use
take 1-2 tablets a day, preferably with a meal and a glass of water or an acidic fruit juice , or as advised by a qualified physician

contains per daily serving  (1 tablet)
Alfa Lipoic Acid 300 mg†
Biotin 333 mcg (100 % RDI)

RDI = Recommended Daily Intake
† = RDI not established

ingredients
active ingredient (alpha lipoic acid, biotin), fillers (microcrystalline cellulose, vegetable magnesium stearate), anticoagulant (silicon dioxide), coating (hydroxypropylmethylcellulose)

storage
keep dry and closed at normal room temperature between 15 - 22°C
keep out of reach of young children

contra-indications
do not take if pregnant or lactating unless under guidance of a qualified physician

allergy information
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)

vegetarians/vegans
suitable for vegetarians and vegans

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