B - Advanced B-complex - benfotiamine, methyl-B12, 5MTHF and pantethine | AOR

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Advanced B-complex

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Retail price: 70,00
56,00
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brand:Advanced Orthomolecular Research
best before:June 2019
appearance:capsules
diet:vegan, hypo-allergenic
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AOR ADVANCED B-COMPLEX was designed to provide the most advanced forms of B vitamins in the most scientifically discerning ratios available. These nutrients help metabolize carbohydrates, proteins and fats for energy, tissue and red blood cell formation, as well as normal growth and development.

key benefits of Advanced B complex
• prevents age-related collagen degeneration
• supports the function of the brain and nervous system
• contains the most effective forms of B vitamins
• maintains cellular energy production

Busy B's
The B complex is a group of essential vitamins with important roles in the body.
Benfotiamine (a bioavailable form of vitamin B1) helps prevent high blood sugar.
Riboflavin (B2) has an important role in energy metabolism.
Niacin (B3) is the base of NAD and NADH, important coenzymes that are required in cellular respiration and energy production pathways.
Coenzyme A is also a critical factor in these pathways, and its production depends on pantothenic acid (B5).
P5P (B6) is required in many biological pathways, including amino acid metabolism and neurotransmitter formation.
Methylcobalamin (B12) is important in the central nervous system.
Benfotiamine and P5P help prevent the formation of advanced glycation end products which lead to age-related degeneration.
Folic acid is needed for red blood cell and DNA formation and is essential during pregnancy.

The Costs of Deficiency
The importance of these vitamins is illustrated by the detrimental health effects that occur when they are deficient. B1 deficiency has been linked to type 2 diabetes.
B12 deficiency leads to neurological disorders and anemia.
P5P deficiency is associated with depression and neuropathy.
Folic acid deficiency is associated with anemia and neural tube defects in infants.

Vitamins in Forms your Body can Use
B vitamins are essential, and it is important to get the right amount in the right forms. Advanced B Complex delivers the biologically active and most efficient forms of these vitamins.

AOR’s Advanced B Complex has a balanced ratio of all the B vitamins but in addition all the B vitamins are present in their already active forms thus enabling a rapid and a powerful action. Moreover, certain percentage of the population have difficulty in converting specific nutrients into the active form e.g. folic acid into the more active 5 Methy Tetrahydro Folate.

The B-complex is an officially recognized grouping of eight essential vitamins. Some sources dispute that number, claiming that there are in fact nine or ten (or more) vitamins within the B-complex, yet within most official, academic, and scientific circles, the number is generally accepted as eight, and these are:

• Vitamin B1 (thiamin)
• Vitamin B2 (riboflavin)
• Vitamin B3 (niacin)
• Pantothenic acid
• Biotin
• Vitamin B6 (pyridoxine)
• Folic acid (folate)
• Vitamin B12 (Methylcobalamin)

There is a great deal of biological activity for which this group of vitamins is responsible, and there is also a great deal of overlap between the respective functions of each vitamin in the B-complex family. However, most of the overlap is centered around the metabolism of the three macronutrients (protein, carbohydrates and fat). Other tasks more specific to certain members of the B-complex group of vitamins include support for the brain and central nervous system, the growth and development of red blood cells, the maintenance of healthy skin and muscle tone, immune function and hormone activity. Metaphorically speaking, the B-complex family of vitamins can be described as the ‘transmission fluid' of the complex automobile that is the human body.

Vitamin B1 ( a.k.a. thiamin): Thiamin is required to convert glucose and amino acids into energy as well as to develop red blood cells and maintain muscle tissue. Thiamin is converted by the body into its active coenzyme form thiamin pyrophosphate (TPP). TPP is a catalyst for pyruvate dehydrogenase (PDH), a key enzyme responsible for the conversion of pyruvate into the all-important acetyl-CoA, which is central to the Kreb's Cycle that in turn generates cellular respiration. In ‘underdeveloped' countries, B1 deficiencies are usually found where foods made from white flour are staples. In the ‘developed' world, where such foods are often fortified with thiamin, the main reasons for deficiencies are alcohol consumption (which impairs thiamin absorption) and poor dietary choices. The most serious deficiencies can lead to degenerative nerve disorders such as beriberi and Wernicke-Korsakoff syndrome, diseases also common among chronic alcoholism.

Thiamin deficiency has also been linked to Type II Diabetes, particularly in the formation of advanced glycation endproducts (AGEs), which occur at an abnormally high rate among diabetics. Simply put, AGEs are cellular proteins that are damaged as a result of being exposed to glucose without the mediating action of a co-enzyme. Increased AGE occurrence is also commensurate with the aging process. Benfotiamine is a lipid-soluble form of thiamin that has been shown in studies to be 5 times more bioavailable than regular thiamin. In fact, clinical trials have demonstrated that benfotiamine can improve nerve function by 30% and decrease nerve pain by 50% among diabetics.

Vitamin B2 (a.k.a. Riboflavin): While playing a role in the energy metabolism of carbohydrates, fats, and proteins, B2 is particularly active in skin and vision health. B2 has long been used as an adjunct in the treatment of neonatal jaundice and has recently been added to anti-migraine protocols as well. Ariboflavinosis is the specific condition caused by riboflavin deficiency and its symptoms include sores around the mouth and swelling of the throat, cheilosis (cracks on the lips), and glossitis (inflammation of the tongue).

Vitamin B3 (a.k.a. Niacin): The derivatives of B3 form the basis of the oxidized and reduced forms of Nicotinamide Adenine Dinucleotide (NAD+ and NADH). The interaction between these coenzymes forms part of the basis (along with the aforementioned acetyl-CoA) of the Kreb's cycle, generating cellular respiration and energy in the form of ATP. B3 also plays an essential role in DNA repair, removing toxic chemicals from the body, and assisting in hormone production. Niacin is also effective at inhibiting the release of low-density lipoproteins (or LDL [bad] cholesterol) into the blood from the liver, making it a treatment of choice for hyperlipidemia.

Deficiency in B3 (combined with a deficiency in the essential amino acid tryptophan) can lead to a disease known as pellagra, characterized by deramatitis, insomnia, diarrhea, weakness and progressive dementia. Most niacin supplements are in nicotinic acid form, which has been associated with a ‘flushing' effect, an unpleasant warming and itching of the skin when taken at significant doses. Inositol hexanicotinate is a form of niacin that is free of this effect.

Vitamin B5 (a.k.a. Pantothenic acid): B5 is needed to form coenzyme A (later becoming acetyl-CoA), which is central to cellular respiration and energy production. Vitamin B5 has also been shown to have a positive effect on cholesterol levels, including lowered total and LDL (bad) cholesterol levels.

Vitamin B6 (a.k.a. Pyridoxine): Vitamin B6 is most commonly known as pyridoxine, but in fact B6 is comprised of three organic forms, namely pyridoxal, pyridoxine, and pyridoxamine. Each represents a different stage in the body's metabolism of this important vitamin. Pyridoxal-5'-phosphate, or P5P, represents the advanced stage of this metabolism, the stage at which B6 has been converted into a coenzyme, a catalyst for at least 113 known essential enzymatic reactions in the body. These include the metabolism of all endogenous amino acids, including such particularly crucial ones as tyrosine, glutamine, cysteine and glycine. P5P is also important for the proper metabolism of essential fatty acids as well as the formation of red blood cells and neurotransmitters, making P5P a factor in optimal cognitive function as well. Notable features of the latter include the fact that P5P is required to convert tryptophan into serotonin as well as to release glucose from glycogen.

Indeed, a deficiency in vitamin B6 can lead to anemia, depression, dermatitis, hypertension, elevated levels of homocysteine and water retention, insomnia, premenstrual tension, irritability, muscle twitching, convulsions, and kidney stones. B6 has been successfully studied for its ability to enhance the immune system and alleviate the symptoms of autism, carpal tunnel syndrome (CTS), anemia, premenstrual syndrome (PMS), hyperhomocysteinemia and other conditions. While the aforementioned studies used conventional B6 supplementation (mainly pyridoxine hydrochloride), it must be remembered that only the P5P converted from pyridoxine can be used for nitrogen and protein metabolism and heme synthesis. This underlines the potential for P5P in supplement form, especially in cases where the body's ability to synthesize it from its organic B6 forms is compromised in any way. In fact, it was found that in patients with impaired liver function, only 33% responded to pyridoxine hydrochloride supplementation with an increase in plasma P5P, where as all of the patients receiving P5P supplementation experienced an increase.

Vitamin B12 (a.k.a. Methylcobalamin): Vitamin B12 has distinguished itself among the B-vitamins with the volumes of research attributable to its specific effects on neurological health. B12 is also very important to the methylation cycle. The successful studies with B12's neuroprotective and neurogenerative benefits were conducted with the methylcobalamin (the active coenzyme) form of B12.

Folic acid is needed for the synthesis of new red blood cells (which carry oxygen throughout the body) and DNA. Folic acid is often prescribed during pregnancy, as it reduces the risk of neural tube defects such as spina bifida in the fetus. A deficiency can also lead to megaloblastic anemia, a specific form of anemia caused by the inhibition of DNA synthesis in red blood cell production, as well as elevated levels of homocysteine. Biotin is another B vitamin that is inolved in the metabolism of protein, carbohydrates and fats, and finally, although not strictly a vitamin, choline is an essential nutrient that is often grouped with the B-complex. Choline is a nitrogen-based organic compound that is found in the lipids of cell membranes. As such, it plays an important role in the structural integrity of cells as well as in the movement of essential lipids across cell membranes and in the synthesis of the key neurotransmitter acetylcholine.

In summation, the B-complex family of vitamins is essential to processing and disseminating the fuel required to keep the evolutionist miracle known as the human body in constant operation. Maintaining the proper intake of this group of vitamins is indeed essential for keeping that operation as optimal as possible for as long as possible.

brand :
Advanced Orthomolecular Research
best before:
June 2019
appearance:
  • capsules
diet:
  • vegan
  • hypo-allergenic
discounts:
  • trending!
  • max 6+ = -15%
quantity discount:
  • any 2+ = -5%
  • any 3+ = -7.5%!
  • any 4+ = -10%
  • any 5+ = -12.5%!
  • any 6+ = -15%
information:
  • quantity discount is valid for any combination of products
  • free shipping costs above €30 (NL) - €60 (BE/DE) or €6 discount above €75 (EU)
  • keep out of reach of young children
  • a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
  • if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
  • books, probiotics and products bought in the SALE can NOT be returned
We frequently receive the question whether it really matters when to use a particular supplement.
Most supplements come with instructions to ingest them with a meal. This is in the assumption that meal contain fat, as fat will aid with absorption through the gut wall. Whether or not this can be your first meal of the day, depends on how much fat it contains. Especially fat-soluble vitamins, such as A,D, E and K need fat for proper absorption.
A work-around is to ingest them together with a larger amount of fish or krill oil softgels if your first meal doesn't contain enough fat.
Another reason take supplements with a meal, is that taking it by itself, can cause nausea or discomfort.
Jarrow Formulas Methyl-B12, Methylfolate Plus Pyridoxal-5-Phosphate (P5P) Lozenge combines the active forms of these vitamins to support DNA and neurotransmitter synthesis and amino acid metabolism. Homocysteine is converted to methionine by methylfolate and B12, or converted to cysteine by P5P-dependent enzymes. P5P is the biologically active form of vitamin B6.
For the longest time we have been led to believe having a high cholesterol diet is dangerous for our health. This assumption was based on research done by Ancel Keys, who compared diets in seven hand-picked countries and concluded a diet low in animal fats (and cholesterol) was best for cardiovascular health.
This assumption started the war on saturated fats  and cholesterol in the mid-1950s  Soon doctors around the world were promoting a low fat, low cholesterol diet.
For the next three decades, millions of people gave up butter for margarine, drank low fat milk and diminished their egg intake.
Rarely have people been so upset about mosquitoes as in this past week: a plague of mosquitoes seems to have arrived in the Netherlands and most surrounding countries.
The reason it is possible to have so many blood thirsty mosquitoes swarm around us, is that mosquito eggs incubate in water puddles as small as a rain gutter, cavities on flat roofs, empty plant pots or pet bowls.
In 14 days or less when it is very warm, larvae become fully grown adults, of which the females start searching for blood. The combination of a semi-monsoon in June and sudden tropical heat in July caused a mosquito 'babyboom'.

recommended use
take one capsule three times daily with food or as recommended by your qualified health care consultant.

contains per daily serving (3 capsules)
B1 (benfotiamine) 100 mg
B2 (riboflavin) 7.5 mg
B3 (niacin) 312 mg
B5 (pantethine) 100 mg
B6 (pyridoxal-5-phosphate) 100 mg
B12 (methylcobalamin) 1000 mcg
Folic Acid (biofolate) 1000 mcg
biotin 500mcg
choline 600 mg
inositol (from Inositol Hexanicotinate, inositol) 384 mg

ingredients
active ingredient (B-vitamins), capsule (hydroxypropylmethylcellulose, chlorophyll)

storage
keep dry and closed at normal room temperature between 15 - 22°C.
keep out of reach of young children

contra-indication
Due to lack of studies involving benfotiamine, do not take when you are pregnant, lactating, or trying to conceive

allergy information
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)

vegetarians/vegans
suitable for vegetarians and vegans

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