B - Methyl B12 5mg & MethylFolate 800mcg + P5P (vit B6) 60 lozenges | Jarrow Formulas
Jarrow Formulas Methyl-B12 /Methylfolate 5mg Lozenge combines the active forms of these vitamins to support DNA and neurotransmitter synthesis and amino acid metabolism. Homocysteine is converted to methionine by methylfolate and B12, or converted to cysteine by P5P-dependent enzymes. P5P is the biologically active form of vitamin B6.
Methylfolate or 5-MTHF is the most biologically active form of folic acid.
QUATREFOLIC is the 4th generation development in folate delivery. With certain inherited errors in metabolism and under a variety of physiologic stresses, the transformation of folic acid into the active form of folate either does not properly take place or is inadequate. Unlike folic acid, this form of folate can cross the blood-brain barrier.
Methyl Folate is needed to support cardiovascular and neurologic health and proper cell division. Folate supplementation during pregnancy has been shown to reduce the risk of neural tube birth defects.
In the US, folic acid is classified as vitamin B9, in the NLs it used to be classified as vitamin B11
Quatrefolic is a registered trademark of Gnosis S.p.A
An Enhanced B-12 & Methyl Folate Lozenge
The Jarrow Formulas lozenge of Methyl B-12 + Methyl Folate + B6 (P-5-P) combines the more bioavailable and biologically active forms of the vitamins B6, B-12 and folate in one easy-to-take format.
Why B-12 Is Important
Methylcobalamin (methyl B-12) is the most bioavailable and best utilized form of vitamin B-12. It is well retained and is active without the need for conversion by the body, unlike other forms. Clinical studies have documented methyl B-12 efficacy in slowing the effects of aging on nerve tissue. Methyl B-12 also appears to help balance brain chemicals and promote neurotransmitter synthesis to improve communication between nerve cells. Studies also demonstrate B-12’s ability to reduce blood homocysteine levels, a pro-oxidant marker that has been linked to arterial injury and other health concerns. Methyl B-12 may also help with irregular sleep patterns, immune function and promoting normal cell growth. Finally, Methyl B-12 plays a strategic role in the production of oxygen-carrying blood cells.
Enhanced Neurological Activity & Reduced Homocysteine Levels
Only methyl B-12 initiates methylation, a process in which methyl (CH3) groups are donated to the myelin sheath that insulates nerve fibers and regenerates neurons. Methyl B-12 also helps synthesize neurotransmitters (e.g., serotonin, dopamine, norepinephrine).
Via methylation, Methyl B-12 is a catalyst for the conversion of homocysteine to methionine, an essential amino acid. Similarly, it helps remove other toxins (e.g., arsenic) from the body.
Risk Factors for Vitamin B-12 Deficiency
Advancing age, medication, and diet are the primary risk factors for vitamin B-12 deficiency.
It is recommended that people over fifty consider supplements and vitamin B-12-fortified foods. Indeed, up to 40 percent of older individuals suffer from reduced stomach acid, which impairs absorption of protein-bound vitamin B-12. Medications for stomach ulcers, heartburn, or GERD inhibit gastric secretions, and impair vitamin B-12 absorption. Any disorder of the digestive tract may increase the risk for vitamin B-12 deficiency. The best sources of vitamin B-12 are animal products, such as meat, eggs, and fish. Therefore, strict vegetarians (those who eat no animal products) are at considerable risk. One study reported vitamin B-12 deficiency in 58% of vegetarians.
Folate (vitamin B9) deficiency leads to a type of anemia. In the 1960s, scientists further discovered that folate deficiency during pregnancy leads to neural tube defects, such as spina bifida and anencephaly, in newborns. In support of this finding, folate supplementation during pregnancy has been shown to reduce the risk of neural tube birth defects.
However, taking folic acid only, especially in the synthetic form, may lead to a more pronounced B12-deficiency, which can lead to other birth defects of their own.
Similarly, folate is needed to support cardiovascular and neurologic health and proper cell division.
Folic Acid versus Folate
Folate is a generic name for a naturally occurring family of compounds containing a pteridine ring linked to p-aminobenzoic acid and containing a polyglutamate tail. The folates found in food consist of a partially bioactive mixture of folate polyglutamates, but these tend to readily degrade during harvesting, storage, and food processing. Up to three-quarters of initial folate activity may be lost. Synthetic folic acid, which is used for fortification, is much more stable because the pteridine ring is not reduced (is in the oxidized state); it also is devoid of the polyglutamate tail.
Concerns have been raised about the potential side effects associated with too much synthetic folic acid intake. In contrast, it is not generally believed that natural folates present such risk even at high levels of intake.
Folate → Dihydrofolate → Tetrahydrofolate ↔ Methylene-THF → Methylfolate (5-MTHF) Bioactive Form
The difference may stem from the biochemical conversion of folic acid to the bioactive form. In humans, the initial reaction is unusually sluggish. It takes place at < 2% the rate as in rats. And just as surprising, the activity of this enzyme can vary amongst humans by 500%. Natural folates, largely avoid this bottleneck since they are already partially on their way toward the bioactive form.
Quatrefolic®- 4th Generation Advantages
Dietary folate easily deteriorates and folic acid is susceptible to bottlenecks and impasses in the conversion to the bioactive form, especially in individuals with certain common genetic variations in metabolism. 5-MTHF itself overcomes one shortcoming by providing the bioactive form. Stabilizing 5-MTHF as the glucosamine salt leads to gains in both stability and bioavailability. Methyl Folate (5-MTHF) is the most biologically active form of folate. Quatrefolic® ((6S)-5-methyltetrahydrofolate glucosamine salt) is the 4th generation development in folate delivery.
Pyridoxal 5-Phosphate (P-5-P)
Pyridoxal 5-Phosphate (P-5-P) is the coenzyme form of vitamin B6 and is necessary for the metabolism of proteins and amino acids. Vitamin B6 is a cofactor in multiple enzyme systems in the body.
P-5-P) assists the reduction of homocysteine to methionine through the cystathionine pathway.
Jarrow Formulas’ Methyl B-12 / Methyl Folate Lozenge
Jarrow Formulas’ Methyl B-12 / Methyl Folate Lozenge provides Methyl B-12, Methyl Folate and Pyridoxal 5-Phosphate in a convenient lozenge form. Methyl B-12 is a readily-absorbed, highly bioavailable form of vitamin B-12 that helps maintain brain-health, vitality, levels of restful sleep and an enhanced mood. It also helps to detoxify homocysteine and other oxidants associated with aging. Methyl Folate is needed to support cardiovascular and neurologic health and proper cell division, especially in those with common genetic variations that limit its biosynthesis. Folate supplementation during pregnancy has been shown to reduce the risk of neural tube birth defects.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
- 12+ items = -25%
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
- books, probiotics and products bought in the SALE can NOT be returned
Pigmentation spots : why do we get them when we age?Do you sometimes look down onto your arms and notice they are covered with white spots that resemble freckles in reverse?
Especially when arms get tanned in summer, these white spots tend to stand out more than ever.
This led me to the idea to look up what can be a cause of this weird pigmentation.
Mine turns out to be one called idiopathic guttate hypomelanosis (IGH), in other words, an unexplained teardrop-shaped lack of pigmentation, which is apparently very common among most people of over 40 years , but may also happen at a younger age. These white spots appear on the shins, legs, arms, and other sun-exposed areas of the body like the face, neck, and shoulders.
Apparently the body experiences a gradual reduction of melanoyctes and skin cells no longer produce pigment, a similar process that causes the graying of hair. The condition is also increasingly being seen in both sexes and darker skinned individuals with a history of long-term sun exposure, which has lead scientists to believe that excessive sun exposure and sun damage is another cause of these white spots.
They are generally 1 to 3 mm in size and commonly show up on the legs before progressing to other parts of the body.
These white spots are not caused by trauma or infection, nor do they indicate an increased risk of skin cancer.
Hereditary factors may be involved because this skin problem seems to run in families.
IGH is not related to vitiligo, in which melanin-producing cells called melanocytes die or are unable to function properly and no longer form melanin.
Other common causes of skin discolorations are
What determines attractiveness?
It is generally accepted as common knowledge how women will feel more sexually attracted to masculin men, but will take far more factors into account when they select future spouses, for which they prefer reliable men who will help raise her offspring.
Another assumption is how women will feel most attracted to masculin-looking men at the most fertile phase of their cycle.
In a recent study where women were shown masculinized and feminized faces of the same men, it was concluded that apparently there is no distinct phase in a women's cycle when they feel less or more attracted, but a bigger influence was whether or not they were in a phase of their life in which they desired to have kids.
When hearing about this study, I immediately wondered why they didn't mention attractiveness of body odour?
Would masculin men not also smell differently from feminine men? In a similar vein, they could have modulated a man's own smell by adding perfume that is perceived as masculin or feminine.
Whomever has followed threads on any perfume forum or has watched popular perfume reviews on Youtube will know that one of the most often asked questions by young and inexperienced men is, "what fragrance is a 'panty dropper'?" In other words, will this fragrance make me so irresistible that women will want to have sex with me?"
The power of positive thinking
Why is stress so hard on the body?When we are stressed, our bodies produce higher levels of cortisol, a hormone that shuts down the thinking center of our brains and activates conflict aversion and protection behaviors. We become more reactive and sensitive. We often perceive even greater judgment and negativity than actually exists. And these effects can last for 26 hours or more, imprinting the interaction on our memories and magnifying the impact it has on our future behavior. Cortisol can be self-inforcing, the more we think about a stressful event, the bigger and longer the impact.
Positive comments produce a chemical reaction too. They spur the production of oxytocin, a feel-good hormone that elevates our ability to communicate, collaborate and trust others by activating networks in our prefrontal cortex. But oxytocin metabolizes more quickly than cortisol, so its effects are less dramatic and long-lasting.
In order to counterbalance the effect of stress, a much higher amount of positive events must happen, which in the real world, is not so easy to achieve.
Another factor which makes it harder to achieve happiness, is that every individual has a 'happiness set point'.
A happiness set point is the point on a continuum of happiness with which we are born.
In early research it was concluded that positive events (such as winning the lottery) and negative events (such as an accident) change our happiness levels for a short period of time, until after a while, we return to the baseline, our happiness set point.
Lately though it has been shown that we *can* change our setpoint. This however, is not very easy and requires hard work!
So let's look at the factors that can help influence happiness!
Why you should combine B12 with BiofolateJarrow Formulas Methyl-B12, Methylfolate Plus Pyridoxal-5-Phosphate (P5P) Lozenge combines the active forms of these vitamins to support DNA and neurotransmitter synthesis and amino acid metabolism. Homocysteine is converted to methionine by methylfolate and B12, or converted to cysteine by P5P-dependent enzymes. P5P is the biologically active form of vitamin B6.
Natural family planningIn the past week another birth control method came under fire for a brief moment: even the intrauterine device (IUD or coil) with the lowest amount of hormones when compared to the birth control PILL, has an oftentimes negative effect all over the body and is not 'just' effective locally. I was like, "duh, what else were you expecting?" .
Afterwards, the news disasppeared rapidly out of the headlines as of course, what else is to the disposition of a fertile woman, who likes to have sex, but doesn't like to get pregnant? A condom!
Indeed, a condom. But what if you have a steady and reliable partner, who isn't likely to get a STD, then it is quite something to always be using 'that' contraption.
Stronger with folic acidFor a very long time already, women that want to get pregnant, are advised to start taking folic acid or biofolate (the preferred form). Like-wise, seniors have started to take it as well, especially in combination with vitamin B12 in order to reduce homocystein levels.
In a new study it was concluded, folates give seniors stronger muscles too!
Big Pharma prevented research into homocysteinMoney-hungry pharmaceutical companies prevented ongoing research into the impoortance of the amino acid homocystein for the development of cardiovascular diseases. The vitamins that can lower homocystein levels are so cheap that it is not possible to make a profit on them. This is what the scientific journalist Emily Yoffe wrote in an older article (2002)
Homocysteine: the real culpritFor the longest time we have been led to believe having a high cholesterol diet is dangerous for our health. This assumption was based on research done by Ancel Keys, who compared diets in seven hand-picked countries and concluded a diet low in animal fats (and cholesterol) was best for cardiovascular health.
This assumption started the war on saturated fats and cholesterol in the mid-1950s Soon doctors around the world were promoting a low fat, low cholesterol diet.
For the next three decades, millions of people gave up butter for margarine, drank low fat milk and diminished their egg intake.
Dissolve in mouth or chew 1 lozenge per day or as directed by your qualified healthcare professional..
contains per daily serving (1 lozenge)
vitamin B6 (as pyridoxal 5-phosphate 2.5mg (125% RDI)
methylfolate (QUATREFOLIC® ) 800mcg (200% RDI)
- as (6S)-5-methyltetrahydrofolic acid glucosamine salt
vitamin B12 (as methylcobalamin) 5mg (83 330% RDI)
RDI = Recommended Daily Intake
active ingredient (methylcobalamin, pyridoxal 5-phosphate, methylfolate, sweetener(Xylitol), filler (cellulose, stearic acid from vegetable source), flavour (natural cherry flavor), acidifier (citric acid), sweetener (rebiana stevia extract), filler (magnesium stearate from vegetable source)
keep dry and closed at normal room temperature between 15 - 22°C.
keep out of reach of young children
If you have a medical condition, are pregnant, lactating, trying to conceive, under the age of 18, or taking medications, consult your healthcare professional before using this product.
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans