We refer you to Pasio's own citrulline product
Jarrow Formulas L-Citrulline is a substrate in the cycle that includes L-arginine and L-ornithine. L-Citrulline supports nitric oxide production, which is important for blood pressure regulation, immune function, healing, as well as helping the liver detoxify ammonia.
Quatrefolic® (Methyl Folate) is the 4th generation of methyl folate which can cross the blood-brain barrier. Methyl Folate is needed to support cardiovascular and neurological health as well as proper cell division.
Gamma tocopherol provides protective capacity from reactive nitrogen species, including nitric oxide beyond its immediate area of utility, that can damage lipids, proteins, and DNA.
Folate and gamma tocopherol work with L-Citrulline to support the production of nitric oxide. Quatrefolic® is a registered trademark of Gnosis
Nitric oxide (NO) is a very simple molecule--composed of one atom of both nitrogen and oxygen--that plays a number of complex biochemical roles. It is a gas and has an extremely short half-life (i.e. seconds) in blood, which allows it to be an effective, transient, short- range signaling molecule.
NO is most prominently known for its effects on blood vessel vasodilation—or relaxation. In fact, the 1998 Nobel Prize in Physiology or Medicine was awarded to a trio of researchers for “for their discoveries concerning nitric oxide as a signaling molecule in the cardiovascular system.”
Jarrow Formulas’ L-Citrulline with 5-methyltetrahydrofolate (5-MTHF) and gamma-tocopherol is designed to support NO production and signaling through complementary modes while balancing related nitrogen cycles.
Maxing & Relaxing Citrulline
L-citrulline is a non-essential alpha amino acid that is a precursor to L-arginine and derives its name from watermelon, Citrullus lanatus. Watermelon is one of the best food sources of citrulline, but is only present in small quantities (0.7-3.6 mg per gram fruit). L-citrulline is also produced from glutamine and ornithine in the intestinal mucosa. This is one reason why bowel problems, such as celiac disease, can lead to depressed levels of citrulline and arginine. In fact, citrulline levels are used as a biomarker of proper bowel function.
Once absorbed, citrulline passes through the liver unchanged and reaches the kidneys where it is converted into arginine and circulated throughout the body. About 75% of the citrulline that reaches the kidneys is converted to arginine. Arginine is a precursor to nitric oxide; but, interestingly, citrulline increases blood levels of arginine more than consuming arginine itself. In contrast to citrulline, ingested arginine is metabolized to urea to a large degree. Contrary to common supplement sense, L-arginine may not support positive nitrogen balance quite as well as is believed due to this conversion to urea.
Many sports and gym enthusiasts seek to increase NO production in an effort to widen blood vessels via endothelium-dependent nitric oxide mediated vasodilation. The rationale is that better gas exchange and nutrient delivery, including amino acids to regenerate muscle, that result from increased blood flow through widened vessels will lead to increased performance and quicker recovery. L-citrulline is a better means to support nitric oxide levels than consuming large quantities of arginine. Animal data also suggests that L-citrulline can improve endothelium-dependent vasodilation, relaxing arterial smooth muscle by an effect on cyclic-GMP.
Methylfolate & Nitric Oxide Synthase
Folate is a generic name for a naturally occurring family of compounds containing a pteridine ring linked to p-aminobenzoic acid and containing a polyglutamate tail. Folic acid is simply the pteridine ring without the polyglutamate tail. The production of the active form of folate in the body, 5-methyltetrahydrofolate (5- MTHF, a.k.a. methylfolate), requires two hydrogenation steps and a methylation reaction. However, the final conversion step from methylene-THF to 5-MTHF is lacking in 10% of the population. Another 40% convert only a limited amount. For these people, folic acid utility at questionable levels and elevated homocysteine levels may be observable.
The connection to cardiovascular and blood pressure health may be more intimately related to another critical biomolecule, tetrahydrobiopterin (BH4), than to homocysteine per se . BH4 is an essential cofactor for nitric oxide synthase (NOS) and possesses the same structure as the head-group of methylfolate minus the methyl group. Since methylfolate is structurally similar to BH4, it looks and acts the same in some areas of the body. As such methylfolate can fit into the active sites of native BH4 enzymes and send similar messages. This is the case with a form of NOS expressed in the vicinity of blood vessels, endothelium dependent nitric oxide synthase (eNOS). In fact, methylfolate has been found to exert beneficial effects on blood pressure regulation by modulating endothelial function and vascular superoxide production, preventing peroxynitrite-mediated BH4 oxidation, and improving eNOS coupling.
Jarrow Formulas’ L-Citrulline supports nitric oxide production, which is important for blood pressure regulation, immune function, healing, as well as helping the liver detoxify ammonia. Quatrefolic® (Methylfolate) is a biologically active form of folate needed to support cardiovascular and neurological health. Gamma tocopherol works with L-citrulline and methylfolate to support the production and function of nitric oxide.
- Kyowa Hakko®
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
- 6+ items = -15%
- any 2+ = -5%! (iDEAL/Bancontact/bank)
- any 3+ = -7.5%!
- any 4+ = -10%!
- any 5+ = -12.5%!
- any 6+ = -15%!
- in stock
- <€30: €4+ (NL) - €7+ (EU)
- quantity discount is valid for any combination of products
- free shipping above €30 (NL) - €50 (BE/DE) or €7 discount above €50 (EU)
- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
- books, probiotics and products bought in the SALE can NOT be returned
Take 1 tablet per day with food or as directed by your qualified healthcare professional.
contains per daily serving (1 tablet)
L- citrulline (free form) 1000mg †
folate (as Quatrefolic®) (6S)-5-methyltettrahydrofolic acid glucosamine salt) 30mcg 8% RDI
gamma tocopherol 10mg †
(from natural mixed tocopherol complex)
† = Recommended Daily Intake not established
active ingredient (L-citrulline, folate and gamma tocopherol), filler (cellulose, stearic acid (vegetable source)) , anti-coagulant (silicon dioxide), filler (magnesium stearate (vegetable source))
keep out of reach of young children
If you have a medical condition, are pregnant, lactating, trying to conceive, under the age of 18, or taking medications (especially blood pressure medications), consult your healthcare professional before using this product.
The elderly should frequently check B12 status; folic acid may mask pernicious anemia.
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians/vegans