Jarrow Formulas Glutamine 1kg powder is widely used by people with an upset gut lining as L-glutamine helps the intestines absorb fluid and important nutrients.
Glutamine is the most abundant amino acid in the human body and is involved in many metabolic processes. Skeletal muscles are the primary sites of glutamine concentration. Glutamine protects muscle tissue and supports immune function during periods of immune and muscular stress.
Glutamine supplementation supports protein synthesis as well as the rate of glycogen production (by serving as a carbon donor). Glutamine is also a major source of fuel for enterocytes (intestinal cells) and supports the integrity of the intestinal lining as well as it assists in nucleotide synthesis by lymphocytes.Especially endurance athletes will benefit from supplementing with glutamine.
Jarrow Formulas L-Glutamine is manufactured in Japan by microbiological fermentation and is USP/FCC grade. This product is 100% L-Glutamine and contains NO other substance.
• improves the integrity of the small and lower intestine
• shortens recovery after sickness or burns in otherwise healthy individuals
• suitable for vegans
Although it is a nonessential amino acid, L-glutamine has become the focus of extensive scientific interest because of its important physiologic role. Since the 1980s, many researchers have come to regard glutamine as “conditionally essential.”
Conditionally essential nutrients are those which the body can produce in quantities sufficient to maintain health under normal circumstances, but for which the body’s needs will outstrip synthesis under various conditions.
In the case of glutamine, food restriction, and other forms of physical and/or mental stress could cause the body to require more glutamine than will be available without supplementation. Under non-stressful conditions, adequate glutamine is synthesized primarily from glutamic acid, valine and isoleucine. However, stress can drop the glutamine levels in the blood as much as 30% and the levels in the muscles as much as 50%.
Glutamine is used for enhancing exercise performance because it supports recovery and immune function. For similar reasons and for other explained below, it promotes the health of the gastrointestinal tract and is sometimes suggested to support and stabilize mood, for use by dieters and for alcohol withdrawal support.
Mechanisms of Action
Glutamine is used not only in the muscles, but also in the metabolism of the immune system, the intestinal tract, the kidneys, gallbladder, pancreas and liver. Among amino acids, glutamine uniquely serves as a preferred energy source for rapidly dividing cells, such as those of the intestinal wall and the lymphatic system. It acts as a regulator of the body’s acid-base balance ––that is, it helps to maintain the proper pH of the system –– through the production and removal of ammonia. This explains part of its importance for liver and brain health. When glutamic acid is combined with ammonia, it produces glutamine.
Glutamine is the an amino acid that readily passes through the blood-brain barrier. It serves as a precursor for both the stimulating neurotransmitter glutamic acid and the calming agent known as gamma-aminobutyric acid (GABA).
Interestingly, glutamic acid does not cross the blood/-brain barrier. Glutamine is very important for muscle regeneration because it is a carrier of nitrogen between tissues and because it is an important precursor of nucleic acids, nucleotides, amino sugars, and proteins.
A series of dose-response studies was conducted to evaluate the clinical safety, pharmacokinetics and metabolic effects of L-glutamine administered to humans. Initial studies in normal individuals evaluated the short-term response to oral loads of glutamine at doses of 0, 0.1, and 0.3 g/kg. A dose-related increase in blood glutamine occurred after oral loading and elevation of amino acids known to be end products of glutamine metabolism occurred (including alanine, citrulline, and arginine). No evidence of clinical toxicity or generation of toxic metabolites (ammonia and glutamate) was observed.
Safety, Adverse Reactions and Interactions
Orally and intravenously glutamine seems to be well tolerated.
Glutamine has been shown to be safe in doses up to 40 grams per day. Significant side effects have not been reported in clinical studies.
However, mania has been reported in people with bipolar disorder and supplementation with glutamine and glutamine should not be taken by persons at risk of bipolar disorder or diagnosed with it.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
- available by July
- €30+: €0 (NL) - €2+ (EU)
- free shipping above €30 (NL) - €50 (BE/DE) or €7 discount above €50 (EU)
- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
- books, probiotics and products bought in the SALE can NOT be returned
Pets and your health
The strength of the human animal bond has been known for a long time, but scientific studies were only conducted fairly recently.
The very first study was published only about 40 years ago when 2 American psychology researchers measured what happens physically when a person pets a friendly and familiar dog. They found that the person's blood pressure lowered, heart rate slowed, breathing became more regular and muscle tension relaxed-all of which are signs of reduced stress.
A healthy gut, a healthy brain
Few people realize how the amount of microbes residing in our gut between the mouth and the end of the large intestine outnumber the amount of human eukaryotic cells by ten to one. This complex ecosystem is formed mainly by bacteria, but also viruses, archae, protozoa and fungi.
Even less known is how gut microbes lays a major role in host health by shaping the development of the immune system, metabolizing dietary nutrients (such as fatty acids, glucose and bile acids) and drugs, digesting complex indigestible polysaccharides and synthesizing vitamins and bioactive molecules.
Throughout different life stages, various changes occur in the microbial diversity of humans.
While babies are massively 'inoculated' with microbes from their mother during birth, smaller amounts enter the baby's gut via the bloodstream and placenta.
After birth, the composition of the gut microbes in the infant changes slowly with age, and stays mostly the same until old age.
While the composition of the gut microbes don't change much in a healthy adult, that is not to say that they aren't vulnerable to outside factors, such as lifestyle, use of antibiotics or even vaccinations, and overall health.
However, outside those factors, diet is one of the most important factors for gut health.
A change in a diet, especially by eating more or less fiber can change the composition of the gut microbitics within a few days. When this change is negative, a dysbiosis can result, characterized by an overgrowth of potentially pathogenic organisms.
This change in the delicate balance between 'good' and 'bad' organisms will result in a 'leaky' gut because of a more porous gut lining and cause chronic inflammation, which can even influence our brain because it also affects our central nervous system. So, as incredible as it sounds, an unhealthy diet can cause you to have an unhealthy brain as well.
This makes it easier to understand why an increasing amount of people try to improve gut health.
Fears about contamination of eggs or supplements
In the past week of early June, a lot of fear was placed in the heart of the public of both Dutch, German and French customers, when officials from the National Food Safety Board announced eggs had to be destroyed due to contamination with a banned substance, called fipronyl.
The reason this happened, is that fipronyl is an amazingly effective insecticide that was perfectly legal for use in stables where egg laying poultry live. This insecticide was however banned from January 1 onwards for use on animals in the food chain, with the main reason behind the ban being its toxicity to bees.
What causes muscle soreness?Delayed onset of muscle soreness (DOMS) is a type of pain that most will experience after doing unusual exercise for the first time. There have been several theories to as what causes muscle soreness. At first lactic acid was blamed, but lactic acids disappears quite rapidly and the time period between exercise and soreness too large.
improving gut function
take 2 gram (one teaspoon) up to 5 times a day, mix it with water or acidic fruit juice in between meals
strengthening immune system
take 4 gram (two teaspoons) up to 5 times a day, mix it with water or acidic fruit juice in between meals
contains per daily serving (1 scoop = 2 grams)
L-glutamine 2g †
† = Recommended Daily Intake not established
keep dry and closed at normal room temperature between 15 - 22°C.
keep out of reach of young children
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans