Source Naturals D-Mannose contains 500mg D-mannose. Imbalances of the urinary tract are widespread, and it is estimated that 20 percent of women will experience them.
Source Naturals D-Mannose supports the health of the entire urinary tract: the urethra, bladder, ureter, renal pelvis and the renal parenchyma. D-Mannose is a monosaccharide hexose sugar, naturally found in some trees, berries and fruits, such as cranberry. It complements the body's natural cleansing process.
D-Mannose is a simple carbohydrate sugar similar in structure to glucose. Some unfriendly bacteria have lectins (adhesion molecules), which bind to residues of mannose in the epithelium of the urinary tract. Some clinical experience suggests that supplemental D-Mannose acts as a molecular "chaff" to which bacteria bind, preventing them from binding to urinary tract cells.
Urinary tract infections
Most urinary tract infections (UTIs) are caused by a strain of E. coli which attach to and invade cells in the bladder. When bladder cells are shed, the bacteria can escape and infect new cells, creating a nasty cycle of recurring infections. The first and most crucial step of infection is the adherence of the bacteria to the wall of the urinary tract. E. coli have arm-like extensions with sticky ends that they use to latch onto their target cell. If the bacteria cannot adhere to cells, they cannot cause an infection.
A synergistic combination
D-Mannose is a simple carbohydrate that is found on cell walls. UTI-causing bacteria recognize and latch on to D-mannose, which then allows them to infect the cell. Supplemental D-Mannose acts as a molecular decoy to prevent bacteria from attaching to and infecting bladder cells. Cranberry extract, on the other hand acts by acidifying the urine and also by reducing bacterial adhesion to the urinary tract wall. Together, D-mannose and cranberry provide a superior solution for the prevention and treatment of UTIs.
A simple solution
Most UTIs are treated with antibiotics, which have negative side effects and the problem of antibiotic resistant bacteria. D-mannose and cranberry extract provide a natural, simple solution with no known side effect.
What causes Urinary Tract Infections?
Although urinary tract infections (UTIs) can involve a variety of different bacteria species (including Staphylococcus saprophyticus and some enterococci species), nearly all infections of the lower urinary tract and bladder are caused by a few strains of E. coli bacteria called uropathogenic Escherichia coli (UPEC).
Various harmless strains of E. coli are normally present in the body - but they don’t belong in the urinary tract.
The invading UPEC take advantage of receptors naturally found on the cells lining the urinary tract. Like pirates in an old movie, UPEC use “grappling hooks” called type I pili to first hook on to these receptors, and then to invade the cell. Once inside the cell, these pathogens can live and reproduce in safety, shielded from many of the body’s defensive immune responses.
The role of D-Mannose in the prevention and treatment of UTI’s
Pathogenic E. coli bacteria’s pili “grappling hooks” are specially designed to attach to a simple carbohydrate called D-Mannose, which is found on the cell surface receptors of the urinary tract host cells. If you can interfere with the binding of between the bacteria and D-Mannose on your urinary tract cells, then you can also prevent UPEC from getting a foothold for adherence and infection. One way to do this is by using D-Mannose itself. When isolated urinary tract cells are bathed in D-Mannose, it acts as molecular “chaff.” The bacteria bind to the D-Mannose in their environment instead of to the D-Mannose on the cells. This gums up their pili and prevents them from hooking onto urinary tract cells
Again, not all UTIs are caused by UPEC. So if you try a course of D-Mannose and infection persists, it is likely not caused by these E. coli bacteria but by some other pathogen. In that case, don’t just keep going on with the supplement in hopes that it will eventually “kick in:” discontinue use of D-Mannose and consult a physician for treatment appropriate to your case. But for the great majority of urinary tract infections, D-Mannose offers a safe, natural option with a simple, ingenious rationale, no known side-effects, and a great reported success rate.
- gelatin caps
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
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take 1 capsules once or twice a day
contains per daily serving (1 capsule)
active ingredients (D-mannose), filler (maltodextrin, dibasic calcium phosphate, silica, and magnesium stearate), capsule (gelatin)
keep dry and closed at normal room temperature between 15 - 22°C.
keep out of reach of young children
warning and contra-indication
If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)