Jarrow Formulas PS-100 120 capsules contains phosphatidylserine (PS), a phospholipid nutrient found in fish, green leafy vegetables, soybeans and rice, which is essential for the normal functioning of neuronal cell membranes and activates Protein kinase C (PKC) which has been shown to be involved in memory function.
PS has been investigated in a small number of double-blind placebo trials and has been shown to increase memory performance in the elderly.
Mike Kingsley a British scientist conducted a study with sprinters and concluded that PS increases both sprinting performance and endurance. In one study Kingsley used cyclists. They were given 750 mg of PS on a daily basis for a period of 10 days. The cyclists were able to put out the same level of performance for at least a longer period with VO2max of 85%. Kingsley believes that the mechanism behind PS must have something to do with the way cells communicate with each other or it might be that PS allows cells to renew themselves at a higher pace by delivering proteins made from within the cells to the Golgi apparatus that transports nuclei outside to the cell membrame where new cells are formed. The real mechanism is still unclear. But the popular theory that PS may blunt cortisol is no longer supported by the new studies.
• shown in studies with athletes to reduce recovery time after strenous exercise
• helps the body to counter attack the risk of early onset age related brain disease
• children who complement their daily food intake with phoshoplipids are more likely to learn faster and easier than those who don not get their optimal intake levels on a daily basis
Phosphatidylserine (PS) and other phospholipids are the major components of the cell membrane, where they contribute to membrane permeability and fluidity. Both permeability and fluidity impact cell-to-cell communication by regulating the movement and functionality of various molecules. PS is also found in the mitochondrial membrane, where it plays a similar role as in the cellular membrane but may also serve as a metabolic reservoir for other phospholipids.
In the brain, PS is an abundant phospholipid where it is a major building block for nerve cells. Its fundamental functionality is critical to neurotransmission and the normal brain functions that are required for healthy cognition, mental performance, attentiveness, and reaction time. In animal models, levels of PS in the brain have been shown to decline with age. However, only small quantities of phosphatidylserine are present in dietary sources.
The Aging Brain
When PS levels decline, the brain can begin to subtly change in a number of ways. Memory is often a foremost concern. As such, much of the PS research has involved older individuals with suboptimal short-term memory function. Nevertheless, a significant amount of published clinical research has demonstrated that PS supplementation also supports other cognitive parameters.
For, example one multi-center, placebo-controlled study evaluated the effects of oral PS supplementation (300mg/day) in 494 elderly patients. Enhancements in behavioral parameters, including motivation, initiative, interest in the environment, and socialization were observed. In another study older individuals without any symptoms of dementia received 300mg/day of PS for 30 days. At the end of the study, those who had received PS showed benefits in mood, memory, and behavioral symptoms, as well as neurochemistry.
PS has a very favorable benefit-to-risk profile. Most of the research on PS for cognitive support in adults suggests 300 mg is an adequate daily serving.
The Stressed Body
Cortisol is an important hormone secreted by the adrenal glands as part of the “fight or flight” response. It is a catabolic stress hormone in the sense that it signals the mobilization of resources to respond to stressful stimuli in the present—to survive. One example of this is how cortisol levels rise after intense exercise, which then signals muscle-tissue breakdown. PS has been found to blunt these effects. In animal studies, administration of PS has been found to improve adaptability to environmental changes and enhance interaction with foreign objects after acute stress stimuli.
Mental stress, particularly when it is chronic, can also affect the brain and negatively impact cognitive performance. And, although the mechanism by which it acts is not entirely clear, PS seems to provide some protection from these effects by buffering cortisol levels. For example, in a double-blind, placebo-controlled trial of healthy individuals exposed to mental stress those who received PS for 6 weeks demonstrated superior performance and a much more relaxed state (decreased Beta-1 power in frontal brain regions) when asked to complete challenging cognitive tasks.
Jarrow Formulas’ Phosphatidylserine (PS) is a natural phospholipid that is an essential component of cell membranes.
Cogni-PS® promotes brain function by helping maintain neuronal membrane fluidity (cell to cell communication), which is essential for cognition, mental performance, attentiveness and reaction time. PS protects against stress by reducing the action of cortisol (catabolic stress hormone).
Cogni-PS® is a concentrated form of phosphatidylserine made by modifying PC in soy lecithin.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
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take 1 capsule with water or acidic fruit juice once up to three times a day with a meal
contains per daily serving (1 capsule)
phosphatidylserine 100 mg †
† = Recommended Daily Intake not established
active ingredients (phosphatidylserine from soy), filler (cellulose), anticoagulant (silicon dioxide), filler (vegetable magnesium stearate), anti-oxidant (natural mixed tocopherols and ascorbylpalmitate), capsule (bovine gelatin)
keep dry and closed at normal room temperature between 15 - 22°C.
contains soy, but no other familiar allergens (wheat, gluten, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)