QH-Absorb 200mg 60 softgels - ubiquinol (reduced co-enzyme Q10) | Jarrow Formulas
Jarrow Formulas QH-absorb 200mg 60softgels
Ubiquinol is the reduced (active antioxidant) state of Co-Q10, the form which is directly used in human metabolism as a lipid-soluble antioxidant. While standard Co-Q10 (ubiquinone) supplements can be activated in the body, this activation can be less efficient in some individuals, based on age, genetics, blood sugar status or level of oxidative stress.
who can benefit from QH-absorb?
Designed for those who seek the superior absorption of ubiquinol for cardiovascular and antioxidant health. May be particularly useful to older consumers who may not activate CoQ10 sufficiently or whose levels have been depleted.
QH-absorb 200mg is in an enhanced stability formula that utilizes the Q-absorb® natural proliposome lipid-soluble delivery system, which has been clinically shown in humans to increase Co-Q10 levels up to 400% (3.2x) over baseline and is 3-4 times better absorbed than chewable Co-Q10 tablets.
Ubiquinol is derived from Co-Q10 that is manufactured by means of a yeast-fermentation process and consists only of the natural trans configuration, the same as is biosynthesized in the human body. Jarrow FORMULAS supports clinical research on Coenzyme Q10.
• the most bioavailable and active form of Co-Q10
• high absorption natural proliposome delivery system
• No synthetic surfactants
• Pharmaceutical Grade Kaneka QH
Ubiquinones are a series of homologous molecules that possess a quinone active center and an unsaturated fatty tail. Ubiquinones are so named because they are widely distributed (i.e. ubiquitous) in nature and throughout the human body. Structurally they are very similar to the menaquinones, like vitamin K2. The quinone group is like a courier for protons and electrons, which is the critical property that allows ubiquinones to act as antioxidants and as important intermediates in energy generation. The fatty tail is composed of isoprenoid subunits, which are five carbon building blocks that help all living things biosynthesize critical components like immune modulators, essential oils and hormones. The number of isoprenoid units in the fatty tail is often denoted in the name of specific ubiquinones. For instance, ubiquinone-10 is made from ten isoprenoid units. Ubiquinone-10 (aka CoQ10, coenzyme Q10, Q) is more commonly referred to as just “ubiquinone.” This is because it is the most prevalent ubiquinone in almost all mammals, including humans.
Concern about CoQ10 levels is especially important in this day and age, because cholesterol lowering drugs (statins) work by inhibiting an enzyme that is also responsible for CoQ10-ubiquinol biosynthesis. As a result, anyone taking statins may have reduced levels of CoQ10-ubiquinol
What is ubiquinol
Ubiquinone and ubiquinol (aka ubiquinol-10, CoQ10-H2, QH, “reduced” CoQ10) are intimately related, as their names suggest. Inside the body, CoQ10 (ubiquinone) can only achieve its important functions in energy production, cardiovascular health and antioxidant protection with the help of ubiquinol. In fact, all of the benefits that have been attributed to CoQ10 necessitate ubiquinol involvement. The two do their work by shuttling electrons and protons back-and- forth, cyclically transforming from ubiquinone to ubiquinol and back again. In energy production, CoQ10 facilitates electron transfer within mitochondrial membranes to produce ATP, the body’s energy currency.
For antioxidant protection, ubiquinol is the “active antioxidant” form of CoQ10. This means that CoQ10 that has not been converted to ubiquinol is inactive as an antioxidant. Perhaps this explains why circa 80-95% of total CoQ10-ubiquinol exists as ubiquinol in the blood and in healthy tissues that require its antioxidant function.
Is taking ubiquinol better than taking coQ-10?
CoQ10 and ubiquinol are critically obtained from the diet, but it appears that absorption of CoQ10 may entail conversion to ubiquinol. This conversion occurs as early as in the enterocytes, the absorptive cells in the intestine, and may facilitate the absorption process. Also under normal conditions there are enzymes that help regenerate ubiquinol from spent CoQ10, in the body. Unfortunately, aging and illness can lead to both a reduced ability to regenerate ubiquinol because of decreased enzyme activity and a decreased ability to absorb CoQ10 itself, possibly for the same reason
After about age 45, total CoQ10 levels and ubiquinol levels in relation to CoQ10 tend to decline in various critical tissues. Some physicians have even started to use blood and tissue ratios of ubiquinol to CoQ10 as a biomarker for age- and illness-related oxidative stress. So it may not come as a surprise that taking ubiquinol can provide benefi ts that surpass those obtained from taking standard CoQ10. But where’s the evidence?
QH-absorb clinical research
Eleven young, healthy adults ingested 100 mg of QH-absorb with food three times daily (100 mg, t.i.d.) for fourteen days. Blood levels of total CoQ10, oxidized CoQ10 and reduced CoQ10 (ubiquinol) were measured at baseline and after fourteen days. This regimen of QH-absorb consumption resulted in a 777% mean increase of total CoQ10 levels compared to baseline and a 100% increase in plasma ubiquinol levels, the “active antioxidant” form of CoQ10.
Two conclusions can be drawn from these study results. First, it appears that even young, healthy individuals can achieve benefits from taking ubiquinol from QH-absorb that surpass taking CoQ10 alone. Previously, it was presumed that only older individuals would benefit from taking QH-absorb as it is known that starting about the age of 40, ubiquinol levels begin to decrease in the body. Second, the 777% increase of total CoQ10 levels measured after taking QH-absorb is more than double the levels achieved by even the best CoQ10 supplements. This suggests QH-absorb is at least twice as efficient in raising blood CoQ10 levels.
Ubiquinol is safe
Scientists have understood the value of ubiquinol for decades. It has just taken that long to figure out a way to stabilize ubiquinol so it can be formulated into a nutritional supplement product. Toxicity studies have shown little problem with taking ubiquinol directly, even at high doses. Plasma ubiquinol levels appear to plateau after two to four weeks of daily ingestion and then return near to baseline two weeks after daily ingestion is discontinued. It also appears that supplementation with ubiquinol does not reduce CoQ10 biosynthesis.
Jarrow Formulas QH-absorb is made with ubiquinol the more bioavailable, active-antioxidant form of CoQ10. It utilizes the Q-absorb natural, proliposomal delivery system for enhanced absorption beyond that of ubiquinol alone.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
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take 1 softgel per day with a meal, or as directed by your qualified health care consultant.
contains per daily serving (1 softgel)
Ubiquinol Q10 (Kaneka QH) 200mg †
vitamin E (as gammatocopherol) 4mg†
† = Recommended Daily Intake not established
active ingredients (active coQ10/ ubiquinol), filler (Medium Chain Triglycerides (MCT from coconut oil), phosphatidylcholine, beeswax, rosmarinic acid and ascorbyl palmitate), antioxidant (gamma tocopherol/vitE), softgel capsule (bovine gelatin, glycerin and water), light barrier (carob and caramel extract)
keep dry and closed at normal room temperature between 15 - 22°C.
keep out of reach of young children
contains no other familiar allergens (wheat, gluten, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)