SAM-e 200mg 60 tablets S-adenosylmethionine | Jarrow Formulas
Jarrow Formulas SAM-e 200 60 tabs :SAM-e is an amino acid derivative clinically proven to benefit brain, liver and joint function. Found in all living cells, SAM-e is called “activated methionine”, formed by the combination of ATP and methionine. Methionine supplementation, however, does not elevate SAM-e. Rather, it elevates toxic homocysteine.
SAM-e has undergone many clinical trials involving thousands of patients. Researchers have identified many structure and function-based benefits of SAM-e involving over 40 biochemical processes. It is a biochemical workhorse with various diverse effects on the body, including improving liver function, enhancing cartilage formation and lifting mood.
SAM-e metabolism supports glutathione (GSH) synthesis and glutathione-dependent enzymes, which support liver function. GSH, the chief antioxidant and detoxifier inside cells, scavenges free radicals produced during carbohydrate breakdown for energy. Taurine is another end product of SAM-e metabolism. GSH and taurine are important for liver detoxification.
SAM-e supports brain function by its methylation effects. Methylation is the transfer of a methyl group (one carbon and three hydrogen atoms, CH3) from one molecule to another. SAM-e is the most important of all methyl-donators in mammalian metabolism. Donation of methyl groups supports numerous metabolic processes including brain function, energy production and DNA metabolism.
Neurotransmitters, substances involved in nerve cell communication, are products of methylation. These compounds include L-dopa, dopamine, serotonin, epinephrine and phosphatidylcholine (in lecithin). There is a connection between SAM-e levels and cognitive health. Conversely, increasing serotonin and dopamine levels contribute to brain health and improved mood. SAM-e works quickly; many people feel the effects within a week.
Methylation from SAM-e is critical for creatine production. Creatine metabolites are important for ADP to ATP recycling, and storing energy for immediate needs. Creatine maximizes physical performance, reduces exercise fatigue and improves recovery after exercise.
A healthy young body manufactures all the SAM-e it needs. However, with age, people are less able to produce adequate SAM-e. This may contribute to declining health on many levels. Fortunately, these disturbances are often mitigated by SAMe supplemention.
Methylation of DNA is an important part of DNA repair. De-methylation of DNA contributes to the aging process. Proper methylation, via substances such as SAM-e, positively influences longevity.
Healthy connective tissue
Research has shown that regular SAM-e supplementation helps improve joint health, and is used in Europe by physicians for the management of knee pain.
Not all SAM-e is created equal
SAM-e exists in two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is inactive. Jarrow Formulas SAM-e is predominantly the active form. It is made naturally by microbiological fermentation and then specially processed, without solvents, to preserve 68-80% (S,S) SAM-e, the highest active level available.
SAM-e is a highly reactive molecule and very fragile. It degrades rapidly under high heat or humidity. Improper handling of SAM-e can cause degradation in a matter of hours. Thus, the manufacturing process for Jarrow Formulas SAM-e is done under low temperature and low humidity, and the tablet is enteric coated and blister-packed. Pharmacokinetic studies show that oral supplementation of SAM-e is most effective when enteric-coated by special gastric fluid-resistant polymers, and results in maximum blood levels.
main characteristics of SAM-e
• supports the lubrication of the joints
• supports the brain function
• supports proper methylation which in turn slows the aging proces of the body
• supports the synthesis of glutathione (GSH) and glutathion dependent enzymes • essential for detoxification enzymes in the liver
• The most important methyl-donating substance
• Supports the production of healthy connective tissue
• blister packed for ultimate protection
- resists stomach acid
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
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The power of positive thinking
Why is stress so hard on the body?When we are stressed, our bodies produce higher levels of cortisol, a hormone that shuts down the thinking center of our brains and activates conflict aversion and protection behaviors. We become more reactive and sensitive. We often perceive even greater judgment and negativity than actually exists. And these effects can last for 26 hours or more, imprinting the interaction on our memories and magnifying the impact it has on our future behavior. Cortisol can be self-inforcing, the more we think about a stressful event, the bigger and longer the impact.
Positive comments produce a chemical reaction too. They spur the production of oxytocin, a feel-good hormone that elevates our ability to communicate, collaborate and trust others by activating networks in our prefrontal cortex. But oxytocin metabolizes more quickly than cortisol, so its effects are less dramatic and long-lasting.
In order to counterbalance the effect of stress, a much higher amount of positive events must happen, which in the real world, is not so easy to achieve.
Another factor which makes it harder to achieve happiness, is that every individual has a 'happiness set point'.
A happiness set point is the point on a continuum of happiness with which we are born.
In early research it was concluded that positive events (such as winning the lottery) and negative events (such as an accident) change our happiness levels for a short period of time, until after a while, we return to the baseline, our happiness set point.
Lately though it has been shown that we *can* change our setpoint. This however, is not very easy and requires hard work!
So let's look at the factors that can help influence happiness!
When is drinking alcohol bad for your health?In the past decade we were told indulging in one or two glasses of alcohol (just one for women) a day is healthy. This was even one of the many recommendations in the national (Dutch) health guidelines. In the past year though, a drastic change occurred: the recommendation changed into zero to perhaps to a most one glass of alcohol a day! So, what gives?
OCD?! Obsessive behaviourWhomever is actively dieting and counting calories for a prolonged period of time, may have been teased by friends of having OCD. Is counting calories obsessive behaviour?
For an obese person, it is is easier to simply cut calories by cutting entire food groups such as wheat, foregoing desserts, eat from smaller plates or fast intermittently.
For someone at a normal weight trying to get very lean it makes perfect sense to count calories as this requires far more precision.
take 1-2 tablets a day, with water (NOT milk) preferably on an empty stomach preceding a meal or as advised by a qualified physician
For optimal use as a joint supplement, combine SAM-e with JarroSil™ (biologically active silicon)
For optimal use as prevention of hangovers, take before imbibing alcohol
contains per daily serving (1 tablet)
S-adenosyl Methionine 200mg†
(from 400mg SAM-e tosylate disulfate)
† = Recommended Daily Intake not established
active ingredienst (SAM-e tosylate disulfate, riboflavin), fillers (microcrystalline cellulose, silicium dioxide, magnesium stearate from palm oil), preservative (glycerol behenate), anticoagulant (titanium dioxide, talc, triethylcitrate), glycerol palmitostearate, enteric coating (methacrylate copolymers)
keep dry and closed at normal room temperature between 15 - 22°C.
do not take if pregnant or lactating unless under guidance of a qualified physician
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans