SAM-e 400mg 60 tablets - S-Adenosyl Methionine | Jarrow Formulas
Jarrow Formulas SAM-e 400mg 60 tablets :SAM-e is an amino acid derivative clinically proven to benefit brain, liver and joint function. Found in all living cells, SAM-e is called “activated methionine”, formed by the combination of ATP and methionine. Methionine supplementation, however, does not elevate SAM-e. Rather, it elevates toxic homocysteine.
SAM-e has undergone many clinical trials involving thousands of patients. Researchers have identified many structure and function-based benefits of SAM-e involving over 40 biochemical processes. It is a biochemical workhorse with various diverse effects on the body, including improving liver function, enhancing cartilage formation and lifting mood.
SAM-e metabolism supports glutathione (GSH) synthesis and glutathione-dependent enzymes, which support liver function. GSH, the chief antioxidant and detoxifier inside cells, scavenges free radicals produced during carbohydrate breakdown for energy. Taurine is another end product of SAM-e metabolism. GSH and taurine are important for liver detoxification.
SAM-e supports brain function by its methylation effects. Methylation is the transfer of a methyl group (one carbon and three hydrogen atoms, CH3) from one molecule to another. SAM-e is the most important of all methyl-donators in mammalian metabolism. Donation of methyl groups supports numerous metabolic processes including brain function, energy production and DNA metabolism.
Neurotransmitters, substances involved in nerve cell communication, are products of methylation. These compounds include L-dopa, dopamine, serotonin, epinephrine and phosphatidylcholine (in lecithin). There is a connection between SAM-e levels and cognitive health. Conversely, increasing serotonin and dopamine levels contribute to brain health and improved mood. SAM-e works quickly; many people feel the effects within a week.
Methylation from SAM-e is critical for creatine production. Creatine metabolites are important for ADP to ATP recycling, and storing energy for immediate needs. Creatine maximizes physical performance, reduces exercise fatigue and improves recovery after exercise.
A healthy young body manufactures all the SAM-e it needs. However, with age, people are less able to produce adequate SAM-e. This may contribute to declining health on many levels. Fortunately, these disturbances are often mitigated by SAMe supplemention.
Methylation of DNA is an important part of DNA repair. De-methylation of DNA contributes to the aging process. Proper methylation, via substances such as SAM-e, positively influences longevity.
Healthy connective tissue
Research has shown that regular SAM-e supplementation helps improve joint health, and is used in Europe by physicians for the management of knee pain.
Not all SAM-e is created equal
SAM-e exists in two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is inactive. Jarrow Formulas SAM-e is predominantly the active form. It is made naturally by microbiological fermentation and then specially processed, without solvents, to preserve 68-80% (S,S) SAM-e, the highest active level available.
SAM-e is a highly reactive molecule and very fragile. It degrades rapidly under high heat or humidity. Improper handling of SAM-e can cause degradation in a matter of hours. Thus, the manufacturing process for Jarrow Formulas SAM-e is done under low temperature and low humidity, and the tablet is enteric coated and blister-packed. Pharmacokinetic studies show that oral supplementation of SAM-e is most effective when enteric-coated by special gastric fluid-resistant polymers, and results in maximum blood levels.
main characteristics of SAM-e
• supports the lubrication of the joints
• supports the brain function
• supports proper methylation which in turn slows the aging proces of the body
• supports the synthesis of glutathione (GSH) and glutathion dependent enzymes • essential for detoxification enzymes in the liver
• The most important methyl-donating substance
• Supports the production of healthy connective tissue
• blister packed for ultimate protection
- resists stomach acid
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
- books, probiotics and products bought in the SALE can NOT be returned
take 1 tablet a day, with water (NOT milk) preferably on an empty stomach preceding a meal or as advised by a qualified physician
For optimal use as a joint supplement, combine SAM-e with JarroSil (biologically active silicon)
For optimal use as prevention of hangovers, take before imbibing alcohol
contains per daily serving (1 tablet)
S-Adenosyl Methionine 400mg
(from 800mg of SAM-e tosylate disulfate)
active ingredients (SAM-e tosylate disulfate, riboflavin), fillers (microcrystalline cellulose, silicium dioxide, magnesium stearate from palm oil), preservative (glycerol behenate), anticoagulant (titanium dioxide, talc, triethylcitrate), glycerol palmitostearate, enteric coating (methacrylate copolymers)
keep dry and closed at normal room temperature between 15 - 22°C.
Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using. Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAM-e.
this product contains no wheat, no gluten, no soy, no dairy, no egg, no fish/shellfish, no nuts/tree nuts.
suitable for vegetarians and vegans