Jarrow Formulas TMG or trimethylglycine is highly effective methyl donor. Methyl donors, such as TMG and folic acid, are required for converting homocysteine back into methionine and for the accurate synthesis of DNA and RNA, which is essential for the production of normal cells.
Methylation is inhibited by inadequately functioning key enzymes, excessive protein and fat intake, poor diet, inadequate intake of methyl groups, coffee, alcohol or by smoking. Impairment of methylation results in abnormal cell synthesis and elevated levels of homocysteine, a toxic amino acid and a serious health risk.
For athletes, TMG is interesting because it can increase the work capacity of fast twitch muscle fibers, resulting in an increased endurance capacity and a raised lactate threshold. TMG is also interesting for strength athletes who use creatine or citrulline supplements , because a methyl-group is needed for complete conversion.
What is homocysteine and why does it matter?
Homocysteine is sometimes called the “new cholesterol” because of its role in cardiovascular health. High blood levels of this compound are damaging in themselves but elevated readings may also be indicative of sluggish homocysteine metabolism. In addition, homocysteine levels are raised by such factors as poor diet, smoking, genetic predisposition and low levels of B vitamins (folic acid, B6, and B12).
The essential amino acid methionine, which comes only from the diet, is “used up” by the body to help donate a methyl group (CH3 - one carbon linked to three hydrogen atoms) to processes going on in every cell. These processes lead to the conversion of some of this methionine to homocysteine, and then into homocysteine thiolactone. This latter compound is a highly toxic metabolite or byproduct. The remethylation of homocysteine, with the help of folic acid, vitamin B12 and trimethylglycine (TMG), converts homocysteine back into methionine.
The methionine-homocysteine axis must be kept working smoothly and efficiently to reduce the levels of toxic homocysteine. A certain amount of homocysteine is present in the blood and tissues at any given time, but high levels are undesirable. It is also important to keep levels of S-adenosyl-methionine (SAM-e) high in modulating the methionine-homocysteine axis. Homocysteine poses a threat only when the pathways to its conversion inside the cells are sluggish. When this happens, homocysteine is exported into the blood, where it causes damage.
For optimal health, both the pathway from homocysteine to methionine and SAM-e and the pathway from homocysteine to the amino acid cysteine (and, ultimately, elimination) must be operating smoothly. A build-up in serum homocysteine indicates that either one or both of the transformation pathways are sluggish. Vitamin B6 is the most important nutritional factor for keeping the second “elimination” pathway working smoothly
Link between methyl donors and anti-oxidants
Methylation helps remediate certain toxic compounds in ways typical antioxidants do not. Homocysteine is one of these compounds.
Methyl donors also act to support the transformation of compounds within the cells, such as the production of neurotransmitters and the anti-infl ammatory polyamines, and to protect DNA from damage. In this sense, the protective roles of methyl donors and antioxidants are complementary.
Methyl donors can improve the antioxidant status of the body indirectly by taking on some of the protective duties performed by antioxidants. However, methyl donors also add directly to the body’s antioxidant capacities by increasing the production of the antioxidant glutathione. With the help of vitamin B6, degradation of homocysteine provides precursor sulfur for the biosynthesis of taurine.
Aging and homocysteine levels and reduced methylation
Most of the conditions which are thought to be linked to sluggish homocysteine metabolism are, likewise, linked to the aging process.
The methylation pathway declines with age, and this decline leads to a loss of the detoxifi cation and repair operations which must be continuously renewed to maintain good health. For instance, methylation is perhaps the body’s most important built-in mechanism for protecting cellular DNA. Supplementation with methyl donors thus becomes one of the options which should be considered for maintaining sound health under conditions of stress and advancing years
Methylation for the liver and the brain
Methyl donors play a large role in the liver’s functions, in part because of their ability to support glutathione production for antioxidant protection and bile production for the disposal of toxins. Methyl donors, moreover, are amongst the classic lipotropics, substances which improve the ability of the liver to process fats and alcohol.
The brain is another organ which depends greatly upon methylation. Transmethylation is so pervasive in the formation, release and reuptake of neurotransmitters that it is difficult to pinpoint any one brain mechanism paramount in importance. However, the regulatory mechanisms of the neurotransmitters epinephrine, norepinephrine, serotonin and dopamine all depend on methylation.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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How to cure a hangover
Quite a lot of people wake up the day after a major holiday like the recent King's Day or Liberation Day with a hangover due to imbibing too much alcohol.
The most widespread assumption is that a hangover is caused by not drinking enough water, and therefore those that aren't drunk enough to remember what to do, will drink a few litres of water before going to bed or at least will try to do so the next morning. Other very popular cures are to drink a lot of coffee and eat a hearty egg-based breakfast. Another advice was heard on the radio from a Dutch food blogger who exclaimed how eating toast with honey is a definite cure for hangovers. Around the world a myriad of folk remedies exist for this ancient 'disease'.
Do these remedies actually work and are there some others you didn't think of?
Before we dive into that, let's first discuss the hangover itself.
Big Pharma prevented research into homocysteinMoney-hungry pharmaceutical companies prevented ongoing research into the impoortance of the amino acid homocystein for the development of cardiovascular diseases. The vitamins that can lower homocystein levels are so cheap that it is not possible to make a profit on them. This is what the scientific journalist Emily Yoffe wrote in an older article (2002)
Homocysteine: the real culpritFor the longest time we have been led to believe having a high cholesterol diet is dangerous for our health. This assumption was based on research done by Ancel Keys, who compared diets in seven hand-picked countries and concluded a diet low in animal fats (and cholesterol) was best for cardiovascular health.
This assumption started the war on saturated fats and cholesterol in the mid-1950s Soon doctors around the world were promoting a low fat, low cholesterol diet.
For the next three decades, millions of people gave up butter for margarine, drank low fat milk and diminished their egg intake.
Take 1 tablet, 1 or 2 times per day with a meal, or as directed by your qualified health care consultant. Store in a cool, dry place. Easy-Solv tablets are designed to disintegrate within several minutes of ingestion.
take 2 or 3 tablets 30 minutes prior to a training or competition
contains per daily serving (1 tablet)
trimethylglycine (anhydrous betaïne) 500 mg†
† = Recommended Daily Intake not established
active ingredient (trimethylglycine (betaïne)), filler (dicalcium phosphate, cellulose, stearic acid and magnesium stearate from palm oil)
If you have a medical condition, are pregnant, lactating, or trying to conceive, are under the age of 18, or are taking medications, consult your health care practitioner before using this product.
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans