Jarrow Formulas Vinpocetine , the smart drug for improved memory recall, is a pscyhostimulant and nootropic, derived from tabersonine, an alkaloid extracted from Vinca minor. Vinpocetine supports cerebral blood flow and brain metabolism by increasing cerebral synthesis of ATP, the universal “currency” of energy.
Vinpocetine enhances brain metabolism by improving utilization of oxygen. Vinpocetine also increases the synthesis of several neurotransmitters that affect such critical brain functions as memory recall, focus and mood. These brain functions are dependent on enough energy and oxygen.
• promotes healthy oxygen supply to the brain
• improves memory and mood
• used as smart drug by world class chess players
Powerful support for mental functioning
Jarrow Formulas Vinpocetine is an alkaloid derivative from voacanga seeds. Vinpocetine also can be derived from the related alkaloids found in the periwinkle flower and a few other plants. In Europe, periwinkle extracts have been employed in herbal preparations for nervousness and anxiety. Modern research indicates that vinpocetine supports cerebral metabolism in part by increasing the brain’s production of ATP (adenosine triphosphate), the most important source of readily accessible energy found in the body. The brain’s utilization of glucose (blood sugar) and oxygen is improved by vinpocetine.
Of special interest, not only to the elderly but also to students, is that vinpocetine increases neurotransmitter concentrations critical for learning/memory formation, recall, focus and mood. Vinpocetine selectively improves blood flow in arteries and capillaries in the head and neck areas. Blood flow, glucose availability and oxygen utilization are also improved in the eyes and the structures important for hearing.
Age-related mental decline
With advancing age, numerous factors may lead to declines in memory and cognition. The brain needs energy and oxygen, and must eliminate waste products. The decline in memory and mental acuity associated with aging reflects multiple factors.
• Basic building blocks for neurotransmitters are less available and less effi ciently used.
• Hormonal elements decline drastically by the sixth decade of life
• Deterioration of the vascular system affects blood supply to the brain
• Production of ATP diminishes over time
• Ability of blood to carry and release oxygen is subject to decline
• Metabolism of glucose for energy goes down
Mental decline and degenerative brain disorders generally involve these six areas. Reduced synthesis of neurotransmitters, decreased circulation and diminished cellular efficiency are the enemies of sound memory and mental clarity.
Neurotransmitters and memory
Vinpocetine influences many areas of brain chemistry and brain functioning. Its impact is greatest upon noradrenaline, principally active in the locus coeruleus (LC) area of the brain. Other primary neurotransmitters are dopamine, acetylcholine and serotonin. Dopamine is involved in reward-seeking behavior and memory associated with spatial tasks.
Acetylcholine is most responsible for memory. Serotonin, which regulates mood and sleep, helps control anxiety and depression.
Locus coeruleus neurons decline in number with age, which strongly influences cognition and information processing. Animal studies have demonstrated that vinpocetine improves the rate of LC neuron firing. Vinpocetine contributes to memory by supporting cognition and awareness.
Memory, however, depends upon many factors. Improved cerebral blood flow is a benefit that compounds such as vinpocetine and ginkgo biloba contribute to.
Vinpocetine shows four main pharmacological and biochemical actions:
(1) selective enhancement of brain circulation and oxygen utilization,
(2) increased tolerance toward inadequate oxygen and reduced blood flow,
(3) inhibition of phosphodiesterase (PDE) enzyme, and
(4) improvement in blood flow and reduction in platelet aggregation as a result of effects on PDE.
These mechanisms suggest numerous possible benefits. In a double-blind placebo-controlled study, 20 mg vinpocetine was given twice per day to subjects with long-term reduced circulation to the brain. After 45 days, subjects had greater mental alertness, reduced confusion, enhanced recall of recent events, diminished anxiety, decreased fatigue, and greater emotional stability
Not just for the elderly
Over 100 clinical trials performed with vinpocetine have involved mostly elderly subjects and focused on memory. However, several studies using younger, healthier volunteers have demonstrated enhanced short-term memory. Thus, vinpocetine may benefit students, who need to memorize large amounts of information in short periods of time.
Other possible uses
Reduced circulation, increased blood viscosity and membrane rigidity in red blood cells can lead to blood flow problems in the inner ear, which could affect hearing and balance.
Similarly, blood flow plays a role in eye health. Platelet “clumping” can impair blood supply through the microvessels that serve the retina, affecting macular health and eye pressure. Supplementation with vinpocetine supports proper circulation to maintain tissue health and integrity.
Through its effects on PDE, vinpocetine might also help people with urinary incontinence. In a small trial among 19 patients, 58% reported improvements in clinical symptoms or bladder function tests. Vinpocetine has been recommended in several recent reviews for controlling female urinary incontinence.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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The power of positive thinking
Why is stress so hard on the body?When we are stressed, our bodies produce higher levels of cortisol, a hormone that shuts down the thinking center of our brains and activates conflict aversion and protection behaviors. We become more reactive and sensitive. We often perceive even greater judgment and negativity than actually exists. And these effects can last for 26 hours or more, imprinting the interaction on our memories and magnifying the impact it has on our future behavior. Cortisol can be self-inforcing, the more we think about a stressful event, the bigger and longer the impact.
Positive comments produce a chemical reaction too. They spur the production of oxytocin, a feel-good hormone that elevates our ability to communicate, collaborate and trust others by activating networks in our prefrontal cortex. But oxytocin metabolizes more quickly than cortisol, so its effects are less dramatic and long-lasting.
In order to counterbalance the effect of stress, a much higher amount of positive events must happen, which in the real world, is not so easy to achieve.
Another factor which makes it harder to achieve happiness, is that every individual has a 'happiness set point'.
A happiness set point is the point on a continuum of happiness with which we are born.
In early research it was concluded that positive events (such as winning the lottery) and negative events (such as an accident) change our happiness levels for a short period of time, until after a while, we return to the baseline, our happiness set point.
Lately though it has been shown that we *can* change our setpoint. This however, is not very easy and requires hard work!
So let's look at the factors that can help influence happiness!
Nootropics, what are they and how do they work?Nootropics is the accepted term for substances that enhance learning and memory function.
Nootropics work in various ways depending on the characteristic of the substance.
Some work by enhancing oxygen transport to the brain, an improved energy turnover in the brain, better neurotransmitter availability, or enhancing the creation of other substances that influence brain activity.
Blood flow and vasodilationVasodilation is the process by which the blood vessels in the body relax and widen, allowing for greater blood flow. One of the main triggers of vasodilation is nitric oxide (NO).
Therefore, anything that increases nitric oxide production in the body will also increase vasodilation.
take 1 capsule with a meal once or twice a day or as advised by a qualified physician
use before an exam
take 2 capsules with a meal twice a day before a major exam and continue during period of examinations or tests or as advised by a qualified physician
contains per daily serving (1 capsule)
vinpocetine 5 mg †
† = Recommended Daily Intake not established
active ingredient (vinpocetine), filler (cellulose and magnesium stearate derived from palm oil), capsule (hydroxypropylmethylcellulose)
Individuals using blood-thinning medications, including aspirin, should not use vinpocetine.
keep dry and closed at normal room temperature between 15 - 22°C.
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans.