AOR XOS contains xylo-oligosaccharides, which is a prebiotic fibre that promotes the growth of beneficial bacteria in the gut. Many different prebiotic fibres exist on the market, however XOS is different. All other prebiotics promote the growth of all bacteria in the gut: good and bad, but XOS selectively promotes the growth of only beneficial microflora, namely the Bifidobacterium strains. As the number of beneficial flora increases, they can inhibit the growth of harmful bacteria by competing with them for resources. These beneficial strains also lower the pH of the intestines to make it an inhospitable environment for harmful bacteria to live. Improved gut microflora has benefits for digestive, cardiovascular, and overall health, especially in improving occasional gastrointestinal disorders.
AOR’s XOS quickly and gently relieves occasional constipation and diarrhea. XOS can be used for the maintenance of metabolic health, and is safe for long term use and in the 2nd and 3rd trimester of pregnancy.
- provides Xylo-oligosaccharide, a prebiotic fibre that promotes the growth of beneficial bacteria in the gut
- quickly and gently relieves constipation and diarrhea
- benefits digestive and metabolic health
- safe for long term use and in the 2nd and 3rd trimester of pregnancy
Not all bacteria are bad
There are at least a 100 trillion microbes of different species that live in our gastrointestinal (GI) tract, some beneficial and some pathogenic. Probiotics, such as Bifidobacterium and Lactobacillus, are the “good” bacteria in the gut, which have beneficial effects on human health. In the early 1900s, the concept that some microorganisms can replace pathogenic microbes in the gut, and therefore improve the ecosystem in the GI tract and confer other physiological benefits, was first introduced. In recent years, there has been extensive scientific effort to “map” the microbes in the gut and understand their role in many different areas of health, wellness and the prevention of disease. It has been suggested that many degenerative diseases, GI and non-GI related, start in the gut as a result of an altered GI microflora (bacteria) where pathogenic bacteria outnumber and outperform beneficial bacteria. This has been implicated in many GI disorders such as irritable bowel syndrome (IBS), constipation and infectious diarrhea, as well as metabolic conditions including diabetes, and obesity, and also disorders of the liver, immune system and mental health. Probiotics flourish by digesting carbohydrates (prebiotics) that are indigestible by normal human enzymes, in doing so they reduce the growth of the bacteria that promotes GI disorders and disease.
Prebiotics and your health
Prebiotics are plant derived fibres which are indigestible by humans and are instead fermented by intestinal microflora. This promotes the growth of the microflora and changes the composition and activity of the GI ecosystem in a beneficial way. When the bacteria in the gut digest and ferment prebiotic fibres, they produce compounds called Short Chain Fatty Acids (SCFAs) such as butyrate, acetate, propionate and lactate. SCFAs play a key role in the body; their functions range from lubricating the GI tract, providing energy to intestinal cells, lowering pH levels (increasing acidity) to reduce the growth of pathogenic bacteria, reducing fat and cholesterol production in the liver, improving intestinal motility to reduce constipation and regulating immunity and inflammation. Prebiotics are a necessary source of energy that the bacteria need to produce these compounds and, without them, pathogenic bacteria have a more hospitable environment in which to grow.
Xylo-oligosaccharide or XOS is a prebiotic fibre that promotes bowel regularity and digestive health. XOS is composed of a short chain of carbohydrate units, known as “oligosaccharides,” which are indigestible by humans and, therefore, non-caloric. As a prebiotic, XOS is digested by the microflora found in the intestines where it is highly effective at increasing the growth of beneficial probiotics, especially bifidobacteria, and improving the gut ecosystem to preferentially favour the growth of “good” vs “bad” bacteria. This improvement in gut ecology is beneficial to human health for a number of reasons; it regulates bowel function to prevent and/or relieve constipation and diarrhea, improves metabolic parameters such as reducing fat production in the liver, increases the excretion of cholesterol in the feces, improves nutrient absorption and improves altered gut microflora in type II diabetics. Furthermore, XOS is considered to be a source of dietary fibre, which has benefits for cardiovascular, metabolic, digestive and cellular health amongst its role in promoting bowel regularity.
The take home message
XOS is one of many different prebiotics including fructo-oligosaccharides (FOS), galacto-oligosaccharides (GOS), raffinose and inulin; however, XOS differs from most other prebiotics in a very important way. All prebiotics promote the growth of gut microflora, good and also bad, but XOS selectively promotes the growth of only beneficial microflora, namely bifidobacteria. As the number of beneficial flora increases, they can inhibit the growth of harmful bacteria by competing with them for resources and lowering the pH of the intestines to make it an inhospitable environment for them to live. XOS is considered to be one of the most beneficial prebiotics because it is highly effective at improving the GI ecosystem compared to the other prebiotics.
The importance of Bifidobacteria
Bifidobacterium species are some of the most abundant types of bacteria in the human colon, They are also found in the vagina and the mouth. Bifidobacterium’s role in gastrointestinal health, and preventing the symptoms of GI disorders, has been well documented. Studies have shown that individuals with inflammatory bowel diseases display abnormal alterations in gut flora (dysbiosis) with reduced “good” bacteria, especially reduced Bifidobacterium. In these individuals, pathogenic bacteria may account for 40% of their gut ecology, a significant factor in inflammation and altered immunity. Reduced Bifidobacterium and increased pathogenic bacteria, such as E.coli, has also been observed in individuals with celiac disease, likely due to carbohydrate restriction, an important source of energy for gut flora. There are numerous strains of bifidobacteria; they have different roles in the body but all preferentially favour XOS over other types of prebiotics.
Probiotics are becoming increasingly popular in the market as we begin to understand the link between gut health and the health of the rest of the body. In recent years, supplement manufactures have begun to include prebiotics such as FOS and inulin into probiotic capsules to encourage their growth; unfortunately, they are typically not in high enough amounts to cause effective growth of probiotics in the intestines. They are also impractical for everyday relief of constipation or diarrhea because they cause bloating and discomfort at high doses. Alternatively, natural laxatives such as Senna are popular because of their fast acting relief; however, long term use of many herbal laxatives is not recommended warranting the need for a safe, fast, and gentle, supplement for constipation relief which addresses the cause of the problem.
XOS is the first xylo-oligosaccharide standalone prebiotic. Unlike other prebiotics, it promotes the growth of beneficial bacteria, namely Bifidobacterium, and relieves constipation and diarrhea quickly without the uncomfortable side effects associated with other prebiotics, laxatives and anti-diarrheals.
XOS for regularity
Constipation is a common digestive concern and affects many people at different points in their life. This is especially true during pregnancy due to anatomical changes of the GI tract. Constipation is a general term that clinically refers to the lack of a bowel movement in 3 days or the feeling of an incomplete bowel movement. Constipation can be chronic or acute and can have a number of causes including obstruction, hormonal and thyroid disorders. One of the most common causes for constipation is the lack of fibre in the diet; fibre promotes the growth of probiotics and is an important component of producing bulk in the stool, which promotes peristalsis or the contraction of the colon, which allows bowel movements to occur. Treatment involves pharmaceutical or herbal laxatives which are generally not recommended for long term use or during pregnancy as they can cause over stimulation of the colon and a habitual dependence on them.
XOS has a 93% efficacy rate on relieving constipation. It does this by promoting the growth of bifidobacteria which is known to regulate the GI tract. It also acts as a bulking agent in the stool to promote peristalsis which can gently, but effectively, cause a bowel movement. Even in severely constipated women, XOS supplementation produced a bowel movement within 3 days. Unlike chronic laxative use, XOS is safe long term and after the 1st trimester of pregnancy. Since it is effective in small doses compared to traditional fibre supplements and other prebiotics, it is less likely to cause gastrointestinal disturbances such as gas and bloating.
Diarrhea is the condition of loose, watery stools. Most diarrhea cases are caused by an intestinal infection by pathogenic bacteria, viruses and parasites which damage the walls of the GI tract so it can’t regulate bowel movements. Infectious diarrhea or “traveler’s diarrhea” is common when visiting developing countries and is most often acquired from contaminated food or water. Diarrhea is also a common symptom of inflammatory GI conditions such as IBS. It is believed that the increase in pathogenic bacteria in IBS individuals is the cause for the inflammation and damage to the wall of the intestinal tract. In studies, XOS was 90% effective at treating moderate diarrhea. Its effects are likely due to its ability to re-colonize the GI by selectively promoting the growth of good bacteria which reduces the population of bad bacteria and inhibits their damaging effects on the GI.
One of the most interesting health benefits of XOS is its effects on improving the absorption of calcium and other nutrients in the GI tract. Many of the nutrients we supplement do not actually get 100% absorbed by the body nor do they reach their target destination; this is especially true for calcium. Calcium is an important mineral for a number of processes in the body and most popularly used to prevent osteoporosis. When it comes to bone strength, improving calcium absorption is far more important than supplementing with more calcium. XOS improves nutrient absorption because it is fermented by gut microflora to form SCFAs; SCFAs are important compounds in nutrient absorption. SCFA’s directly enhance the absorption of calcium, iron and other minerals in the GI tract by promoting the health of intestinal cells, so they can properly absorb nutrients by lowering the pH of the intestines. This keeps the minerals in their most absorbable forms.
Metabolic disorders, such as obesity, diabetes and abnormal cholesterol, are not only diseases of abnormal food intake; they are also connected to overall gut health. Studies have shown that individuals with obesity and type II diabetes have dysbiosis and abnormal ratio of pathogenic bacteria over healthy bacteria. In one study, diabetics supplementing with XOS had not only improved their GI bacterial flora, but also improved their short and long term blood sugar control along with their cholesterol levels. Other studies have shown improvements in subjects’ total cholesterol levels with elevated levels of HDL, the “good” cholesterol. There are a number of proposed mechanisms for how XOS can improve metabolic parameters; it reduces the internal synthesis of lipids (fat) and lipids in the blood stream and increases the excretion of cholesterol through the feces. SCFAs can improve sugar metabolism and regulate insulin activity.
The connection between probiotics and immunity is well studied. Probiotics improve immunity by reducing the number of pathogenic bacteria in the GI tract and improving the gut barrier to reduce the risk of pathogens “leaking” into the circulation. XOS has an immuno-stimulatory effect by increasing the growth of the probiotics which modulate immune function and reduce pro-inflammatory and excessive immune stimulating compounds. This is especially beneficial for those with suppressed immunity such as the elderly and excess inflammation, as in the case of allergies.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
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Separating chaff from the wheat or the importance of indigestible fiberSandwiched in between sugar and the starches are a group of carbohydrates called oligosaccharides, that we never heard much about until recently, and most people probably still have no idea what they are.
About Advanced Orthomolecular ResearchAdvanced Orthomolecular Research was founded in 1991 in response to a supplement industry that capitalized on market trends, did not evolve with the science, and was full of products using low quality forms and small doses to appease the pocketbook at the expense of effectiveness. Since then, AOR has become a leader in innovation and scientific integrity in Canada and around the world, providing you with science-backed supplements that work.
Be kind to your bowels!Probiotics or beneficial bacteria are important for good digestive health. In order to keep these same bacteria happy and thriving, they need to be fed PRE-biotics, in other words, fiber!
Fiber is the undigestable part of vegetable foods. The most common source of fiber are beans and legumes, onions and garlic, cabbage, unpeeled potatoes as well as fruits such as raisins, figs, prunes, berries and (unripe) bananas.
for intestinal regularity and constipation relief.: take 2-4 lozenges daily
to stimulate growth of Bifidobacteria: take 4-6 lozenges daily
as a source of fiber: take 5-6 lozenges daily
Take 2 hours before or after taking other medications and/or natural health products or as directed by your qualified health care consultant.
To maintain adequate fluid intake, take with at least 1 glass of water.
contains per daily serving (1 lozenge)
xylo-oligosaccharide (XOS) 700mg
active ingredients (xylo-oligosaccharides), flavour (monk fruit extract), filler (hyprolose), flavour (natural strawberry flavour), colouring (beet concentrate), filler (tapioca, Arabic gum, croscarmellose, sodium stearyl fumarate)
keep dry and closed at normal room temperature between 15 - 22°C.
keep out of reach of young children
Consult a health care practitioner prior to use if you have been pregnant for less than 23 weeks, if you are taking medications which inhibit peristaltic movement (e.g. opioids, loperamide), or if you are experiencing any of the following: sudden change in bowel habits that has persisted for more than 2 weeks, undiagnosed rectal bleeding, or have failed to defecate following the use of laxative product or have symptoms such as abdominal pain, nausea, vomiting, or fever.
Consult a health care practitioner if symptoms worsen, if laxative effect does not occur within 7 days, or for use beyond 4 weeks.
May cause mild gastrointestinal discomfort such as gas, bloating and cramps.
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans